Table 1. Basal characteriwstics of patients.
| Total | |
| (n = 107) | |
| Age (yr) | 36±12 |
| Sex (M/F) | 64(60)/43(40) |
| Initial disease | |
| cystic fibrosis | 64(60) |
| emphysema | 19(18) |
| others | 24(22) |
| Type of transplantation (single/bilateral) | 16(15)/91(85) |
| CMV mismatch at transplantaion (D+/R-) | 26(24) |
| EBV mismatch at transplantation (D+/R-) | 7(7) |
| Primary graft dysfunction grade III | 15±4 |
| Number of CN-a measurements/24 months | 6±3 |
| Time of follow-up (months) | 41±16 |
| Patients with acute rejection/6 months | 77(72) |
| Patients with BOS grade ≥ I | 40(37) |
| Patients with malignancies | 16(15) |
| Patients with bacterial infections | |
| ≥1 episode | 63(59) |
| ≥2 episodes | 31(29) |
| ≥3 episodes | 15(14) |
| Patients with viral infections | |
| ≥1 episode | 39(36) |
| ≥2 episodes | 20(19) |
| ≥3 episodes | 7(6.5) |
| Patients with fungal infections | |
| ≥1 episode | 31(29) |
| ≥2 episodes | 9(8.4) |
| ≥3 episodes | 2(1.9) |
Data are summarized as frequencies and percentage for categorical variables and as mean±SD for continuous variables. A total of 670 peripheral blood samples (mean of 6±3 samples per patient, range: 2–14) were obtained during the first 24 months following transplantation. Yr: year; M: male; F: female; EBV: empstein barr virus; CMV: cytomegalovirus; CN-a: calcineurin activity; BOS: bronchiolitis obliterans syndrome.