Table 2. Association results of 16 SNPs and age of natural menopause in Chinese women.

SNPs	Chrd	Position	Nearest gene	Allele	Reported studies			Shanghai population
				Reference/Effect	EAFe	Bf	P	EAFe	B f	P	Power	GRSsel g
rs4246511	1	39152972	RHBDL2	C/T	0.187	0.240	1.02×10−16	0.612	0.287	0.002	0.879	Y
rs1635501	1	240107398	EXO1	T/C	0.482	−0.164	8.46×10−10	0.235	−0.019	0.851	0.056
rs2303369	2	27568920	FNDC4	C/T	0.389	−0.175	8.40×10−14	0.139	−0.094	0.455	0.106
rs10183486	2	171699217	TLK1	C/T	0.357	−0.196	2.21×10−14	0.070	−0.166	0.325	0.165
rs4667673a	2	171551661	TLK1	C/G	0.375			0.386	0.144	0.121	0.353
rs4693089	4	84592646	HEL308	A/G	0.488	0.228	1.80×10−19	0.658	0.111	0.213	0.231
rs365132	5	176311180	UIMC1	G/T	0.491	0.39	2.60×10−12	0.504	0.284	0.001	0.869	Y
rs1046089	6	31710946	BAT2	G/A	0.354	−0.213	1.45×10−59	0.336	−0.075	0.400	0.123
rs2153157	6	11005474	SYCP2L	G/A	0.491	0.165	7.76×10−12	0.677	0.166	0.075	0.412
rs2517388	8	38096889	ASH2L	T/G	0.178	0.262	2.47×10−19	0.662	0.071	0.445	0.123
rs2720044b	8	38099744	ASH2L	A/C	0.188			0.265	0.225	0.029	0.610	Y
rs12294104	11	30339475	MPPED2	C/T	0.174	0.225	2.25×10−12	0.102	0.060	0.702	0.073
rs7123626c	11	30282441	FSHB	G/A	0.112			0.036	0.085	0.715	0.064
rs2277339	12	55432336	PRIM1	T/G	0.103	−0.380	3.56×10−13	0.274	−0.164	0.136	0.381
rs4886238	13	60011740	TDRD3	G/A	0.334	0.170	9.31×10−15	0.038	0.013	0.955	0.050
rs7333181	13	111019298	SOX1	G/A	0.120	0.520	2.38×10−19	0.038	−0.135	0.558	0.087
rs2307449	15	87664932	POLG	T/G	0.400	−0.184	9.53×10−11	0.341	−0.211	0.019	0.634	Y
rs10852344	16	11924420	COX6CP1	T/C	0.482	0.168	1.01×10−11	0.847	0.188	0.130	0.356
rs12461110	19	61012475	NLRP11	G/A	0.326	−0.158	8.74×10−10	0.293	−0.201	0.034	0.558	Y
rs12611091	19	60492141	BRSK1	T/C	0.480	0.330	1.10×10−10	0.773	0.285	0.008	0.767	Y
rs1172822	19	60511657	BRSK1	C/T	0.390	−0.49	2.50×10−8	0.095	−0.600	6.64×10 −5	0.978	Y
rs7246479	19	60516144	TMEM150B	G/T	0.480	0.360	2.90×10−12	0.815	0.487	3.75×10 −5	0.993	Y

^aIn LD with GWAS-identified SNP rs10183486 in CEU (r² = 0.863) but not in CHB (r² = 0.005).

^bIn LD with GWAS-identified SNP rs2517388 in CEU (r² = 0.843) but not in CHB (r² = 0.169).

^cIn LD with GWAS-identified SNP rs12294104 in CEU (r² = 0.877) but not in CHB (r² = 0.070).

^dChr: chromosome.

^eEAF: effect allele frequency.

^fPartial regression coefficient was calculated for years per allele change in ANM (years).

^gGRS: genetic risk score, Significant SNPs were selected in the calculation of the GRSsel.