TABLE 3.
ORs (95% CIs) of heart failure according to quintiles of individual plasma phospholipid TFAs in 1576 male physicians from the PHS I1
|
trans 16:1 |
trans 18:1 |
trans 18:2 |
||||||
| Quintile range2 | Model 1 | Model 2 | Quintile range2 | Model 1 | Model 2 | Quintile range2 | Model 1 | Model 2 |
| Q1 (0.018–0.062) | 1 (ref) | 1 | Q1 (0.578–1.158) | 1 | 1 | Q1 (0.159–0.274) | 1 | 1 |
| Q2 (0.063–0.076) | 1.03 (0.75, 1.41) | 0.88 (0.63, 1.24) | Q2 (1.159–1.433) | 0.93 (0.68, 1.26) | 0.88 (0.63, 1.23) | Q2 (0.275–0.333) | 1.15 (0.84, 1.58) | 1.10 (0.79, 1.54) |
| Q3 (0.077–0.089) | 1.14 (0.83, 1.58) | 1.04 (0.73, 1.47) | Q3 (1.434–1.701) | 0.88 (0.64, 1.19) | 0.87 (0.62, 1.22) | Q3 (0.334–0.386) | 0.87 (0.63, 1.20) | 0.88 (0.62, 1.25) |
| Q4 (0.090–0.108) | 1.08 (0.79, 1.49) | 0.96 (0.67, 1.37) | Q4 (1.702–2.071) | 0.87 (0.64, 1.20) | 0.87 (0.61, 1.24) | Q4 (0.387–0.452) | 0.76 (0.54, 1.07) | 0.71 (0.49, 1.02) |
| Q5 (0.109–0.219) | 0.81 (0.57, 1.16) | 0.74 (0.49, 1.10) | Q5 (2.072–3.817) | 0.81 (0.59, 1.10) | 0.83 (0.58, 1.19) | Q5 (0.453–2.705) | 0.65 (0.46, 0.94) | 0.67 (0.45, 0.98) |
| P-trend | 0.34 | 0.23 | 0.17 | 0.37 | <0.01 | 0.01 | ||
| TFA modeled as continuous variable3 | 0.95 (0.84, 1.07) | 0.91 (0.80, 1.04) | 0.91 (0.82, 1.01) | 0.92 (0.82, 1.03) | 0.76 (0.63, 0.91) | 0.78 (0.64, 0.94) | ||
1
Model 1 adjusted for matching factors; model 2 adjusted as for model 1 with additional adjustment for BMI, smoking, alcohol, exercise, diabetes, and atrial fibrillation analyzed by using conditional logistic regression. PHS I, Physicians’ Health Study I; Q, quintile; ref, reference; TFA, trans fatty acid.
2
Values are % of total fatty acids.
3
ORs per SD increase in TFAs (16:1 = 0.03% of total fatty acids, 18:1 = 0.55% of total fatty acids, 18:2 = 0.18% of total fatty acids).