TABLE 6.
HRs (95% CIs) of CAD according to quintiles of dietary TFAs (from FFQs)1
| Quintile of dietary TFA (g/d) | No. of cases/person-years | Model 1 | Model 2 | Model 3 |
| Q1 (ref): 0.88 (0.02, 1.13) | 331/36,911 | 1.00 | 1.00 | 1.00 |
| Q2: 1.35 (1.14, 1.52) | 308/36,567 | 0.94 (0.81, 1.10) | 0.92 (0.78, 1.07) | 0.91 (0.78, 1.07) |
| Q3: 1.70 (1.53, 1.86) | 299/36,391 | 0.90 (0.77, 1.05) | 0.87 (0.74, 1.01) | 0.86 (0.74, 1.01) |
| Q4: 2.05 (1.87, 2.27) | 327/35,569 | 1.00 (0.86, 1.17) | 0.94 (0.81, 1.10) | 0.94 (0.81, 1.10) |
| Q5: 2.61 (2.28, 6.10) | 306/34,894 | 0.95 (0.81, 1.10) | 0.87 (0.74, 1.02) | 0.86 (0.73, 1.01) |
| P-trend | — | 0.73 | 0.17 | 0.13 |
| Modeled as continuous variable2 | — | 0.99 (0.94, 1.04) | 0.96 (0.92, 1.02) | 0.96 (0.91, 1.01) |
1
Quintile values are medians; ranges in parentheses. Number of subjects per model: model 1, 18,750; model 2, 18,321; and model 3, 18,302. Model 1 adjusted for age; model 2 adjusted as for model 1 plus additionally adjusted for smoking, alcohol, exercise, and BMI; model 3 adjusted as for model 2 plus additionally adjusted for diabetes and atrial fibrillation. Analyses were performed by using proportional hazards regression. CAD, coronary artery disease; FFQ, food-frequency questionnaire; Q, quintile; ref, reference; TFA, trans fatty acid.
2
ORs per SD increase in dietary TFAs (0.69 g/d).