TABLE 2.
Multivariate analysis of one-carbon metabolism plasma biomarkers and relative telomere length1
| Plasma concentrations | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-trend |
| Folate (nmol/L) | 8.62 | 13.4 | 20.8 | 38.1 | |
| Model 1 | Reference | 0.82 (0.62, 1.09)3 | 1.10 (0.83, 1.45) | 1.03 (0.78, 1.36) | 0.90 |
| Model 2 | Reference | 0.80 (0.60, 1.07) | 1.06 (0.80, 1.41) | 1.01 (0.76, 1.34) | 0.90 |
| PLP/vitamin B-6 (pmol/mL) | 23.9 | 38.4 | 58.4 | 126.7 | |
| Model 1 | Reference | 1.16 (0.88, 1.52) | 1.06 (0.81, 1.39) | 1.10 (0.84, 1.44) | 0.98 |
| Model 2 | Reference | 1.14 (0.86, 1.51) | 1.01 (0.76, 1.33) | 1.04 (0.78, 1.38) | 0.78 |
| Vitamin B-12 (pmol/L) | 207.2 | 280.4 | 352.8 | 478.1 | |
| Model 1 | Reference | 1.11 (0.84, 1.47) | 1.15 (0.87, 1.52) | 1.21 (0.92, 1.59) | 0.97 |
| Model 2 | Reference | 1.09 (0.82, 1.45) | 1.09 (0.82, 1.45) | 1.15 (0.87, 1.53) | 0.94 |
| Cysteine (nmol/mL) | 227.9 | 265.3 | 303.2 | 369.4 | |
| Model 1 | Reference | 0.73 (0.54, 0.98) | 0.82 (0.61, 1.10) | 0.70 (0.52, 0.94) | 0.12 |
| Model 2 | Reference | 0.71 (0.53, 0.96) | 0.82 (0.60, 1.11) | 0.72 (0.53, 0.98) | 0.16 |
| Homocysteine (nmol/mL) | 7.7 | 9.7 | 11.6 | 15.0 | |
| Model 1 | Reference | 0.95 (0.72, 1.25) | 0.84 (0.64, 1.11) | 0.84 (0.63, 1.11) | 0.62 |
| Model 2 | Reference | 0.90 (0.68, 1.20) | 0.84 (0.63, 1.12) | 0.84 (0.62, 1.12) | 0.57 |
1
Telomere length was dichotomized at the median. Model 1 was adjusted for batch and age (y; continuous) (n = 1698). Model 2 was adjusted for batch, age (y; continuous), smoking (0, 0.1–20, 20.1–40, or >40 pack-years), BMI (in kg/m2; <25, 25–29.9, 30–34.9, or ≥35), and physical activity (nominal quartiles, metabolic equivalent tasks/wk) (n = 1624). The logistic regression model was used to obtain ORs (95% CIs), and the linear regression model was used to obtain P-trend values. PLP, pyridoxal 50-phosphate.
2
Median (all such values).
3
OR; 95% CI in parentheses (all such values).