TABLE 3.
Multivariate analysis of FFQ-measured intakes of one-carbon metabolism dietary factors and relative telomere length1
| FFQ-measured intakes | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-trend |
| Folate (μg/d) | 229.12 | 303.9 | 409.8 | 610.6 | |
| Model 1 | Reference | 0.95 (0.70, 1.27)3 | 0.85 (0.64, 1.14) | 1.04 (0.78, 1.39) | 0.92 |
| Model 2 | Reference | 0.89 (0.66, 1.21) | 0.81 (0.60, 1.09) | 0.99 (0.73, 1.34) | 0.94 |
| Choline (mg/d) | 276.9 | 315.4 | 348.3 | 394.6 | |
| Model 1 | Reference | 1.03 (0.78, 1.37) | 0.99 (0.75, 1.32) | 0.88 (0.66, 1.17) | 0.77 |
| Model 2 | Reference | 1.05 (0.78, 1.40) | 1.04 (0.78, 1.40) | 0.93 (0.69, 1.26) | 0.72 |
| Methionine (g/d) | 1.5 | 1.7 | 1.8 | 2.1 | |
| Model 1 | Reference | 0.95 (0.72, 1.26) | 0.84 (0.64, 1.11) | 0.91 (0.68, 1.21) | 0.96 |
| Model 2 | Reference | 0.94 (0.70, 1.25) | 0.87 (0.66, 1.15) | 0.95 (0.70, 1.28) | 0.98 |
| Riboflavin (mg/d) | 1.4 | 1.9 | 2.9 | 7.7 | |
| Model 1 | Reference | 1.08 (0.80, 1.44) | 1.13 (0.85, 1.50) | 0.98 (0.74, 1.30) | 0.68 |
| Model 2 | Reference | 1.11 (0.82, 1.50) | 1.13 (0.85, 1.52) | 0.98 (0.73, 1.31) | 0.77 |
| Vitamin B-6 (mg/d) | 1.5 | 2.0 | 3.1 | 10.3 | |
| Model 1 | Reference | 0.92 (0.68, 1.25) | 0.96 (0.71, 1.31) | 0.89 (0.66, 1.20) | 0.52 |
| Model 2 | Reference | 0.89 (0.65, 1.23) | 0.93 (0.68, 1.28) | 0.89 (0.65, 1.22) | 0.71 |
| Vitamin B-12 (μg/d) | 4.5 | 7.0 | 9.8 | 14.8 | |
| Model 1 | Reference | 0.85 (0.63, 1.14) | 1.19 (0.89, 1.58) | 0.92 (0.69, 1.23) | 0.75 |
| Model 2 | Reference | 0.82 (0.61, 1.12) | 1.13 (0.84, 1.53) | 0.94 (0.70, 1.27) | 0.55 |
| Alcohol (g/d) | 0.0 | 0.9 | 4.3 | 15.6 | |
| Model 1 | Reference | 1.25 (0.93, 1.66) | 1.35 (1.02, 1.78) | 1.20 (0.91, 1.59) | 0.18 |
| Model 2 | Reference | 1.24 (0.92, 1.66) | 1.22 (0.91, 1.62) | 1.13 (0.84, 1.53) | 0.28 |
Telomere length was dichotomized at the median. Dietary Reference Intakes for women 50–70 y old were as follows: 400 μg folate/d, 1.1 mg riboflavin/d, 1.5 mg vitamin B-6/d, 2.4 μg vitamin B-12/d, and 425 mg choline/d. Model 1 was adjusted for batch and age (y; continuous) (n = 1698). Model 2 was adjusted for batch, age (y; continuous), smoking (0, 0.1–20, 20.1–40, >40 pack-years), BMI (in kg/m2; <25, 25–29.9, 30–34.9, or ≥35), and physical activity (metabolic equivalent tasks/wk; nominal quartiles) (n = 1624). The logistic regression model was used to obtain ORs (95% CIs), and the linear regression model was used to obtain P-trend values. FFQ, food-frequency questionnaire.
Median (all such values).
OR; 95% CI in parentheses (all such values).