TABLE 4.

Associations between one-carbon metabolism SNPs and relative telomere length¹

				Telomere length3
SNP	Gene	MAF	Reference allele2	OR (95% CI)	P
rs1127717 (C, T)	ALDH1L1	0.20	C	0.94 (0.69, 1.30)	0.72
rs4646750 (C, T)	ALDH1L1	0.07	C	1.08 (0.66, 1.79)	0.76
rs2886059 (A, C)	ALDH1L1	0.16	A	1.33 (0.93, 1.90)	0.12
rs2276724 (C, T)	ALDH1L1	0.15	C	1.35 (0.94, 1.93)	0.10
rs2372536 (C, G)	ATIC	0.32	C	1.39 (1.07, 1.82)	0.02
rs3733890 (A, G)	BHMT	0.30	A	1.23 (0.94, 1.61)	0.14
rs9001 (G, T)	CHDH	0.05	G	0.95 (0.50, 1.82)	0.88
rs12676 (A, C)	CHDH	0.30	A	1.04 (0.80, 1.36)	0.78
rs1021737 (G, T)	CTH	0.29	G	1.03 (0.77, 1.37)	0.84
rs2228612 (C, T)	DNMT1	0.06	C	1.22 (0.72, 2.07)	0.47
rs202676 (T, C)	FOLH1	0.22	T	1.11 (0.81, 1.52)	0.54
rs8788 (C, T)	GART	0.17	C	0.99 (0.70, 1.39)	0.93
rs8971 (C, T)	GART	0.24	C	1.05 (0.78, 1.42)	0.76
rs11545077 (C, T)	GGH	0.25	C	0.95 (0.72, 1.24)	0.69
rs11545078 (A, G)	GGH	0.10	A	1.06 (0.66, 1.69)	0.82
rs2236225 (A, G)	MTHFD1	0.45	A	1.01 (0.77, 1.31)	0.96
rs1950902 (A, G)	MTHFD2	0.18	A	1.07 (0.78, 1.46)	0.68
MTHFR 677 (C, T)	MTHFR	0.34	C	0.94 (0.72, 1.24)	0.66
MTHFR 1298 (A, C)	MTHFR	0.33	A	0.78 (0.60, 1.03)	0.08
rs1805087 (A, G)	MTR	0.19	A	0.96 (0.70, 1.32)	0.81
rs1801394 (A, G)	MTRR	0.47	A	0.83 (0.64, 1.07)	0.15
rs1532268 (C, T)	MTRR	0.37	C	0.85 (0.65, 1.12)	0.24
rs2287780 (C, T)	MTRR	0.04	C	0.53 (0.27, 1.06)	0.07
rs16879334 (C, G)	MTRR	0.04	C	0.60 (0.31, 1.19)	0.15
rs162036 (A, G)	MTRR	0.11	A	1.18 (0.78, 1.78)	0.43
rs10380 (C, T)	MTRR	0.09	C	1.16 (0.75, 1.81)	0.50
rs7946 (T, C)	PEMT	0.25	T	0.92 (0.70, 1.21)	0.54
rs1979277 (A, G)	SHMT1	0.29	A	0.90 (0.69, 1.18)	0.45
rs1051266 (C, T)	SLC19A1	0.44	C	0.90 (0.70, 1.16)	0.42

¹The logistic regression model was used to obtain ORs (95% CIs) and P values. MAF, minor allele frequency; SNP, single-nucleotide polymorphism.

²Homozygous genotype of the reference allele was coded 0.

³Telomere length was dichotomized at the median.