TABLE 3.
ORs (95% CIs) of CRC associated with baseline cysteine values1
| Quartiles of cysteine |
|||||
| Model | 1 (≤260 μmol/L) | 2 (>260–282 μmol/L) | 3 (>282–309 μmol/L) | 4 (>309 μmol/L) | P-trend2 |
| n | 500 | 464 | 502 | 468 | |
| All participants | |||||
| Age-adjusted | 1 | 0.88 (0.67, 1.15) | 1.03 (0.78, 1.35) | 0.88 (0.65, 1.19) | 0.61 |
| Multivariate3 | 1 | 0.73 (0.54, 0.98) | 0.86 (0.63, 1.16) | 0.57 (0.40, 0.82) | 0.01 |
| By tumor site | |||||
| Proximal | |||||
| Age-adjusted | 1 | 0.77 (0.54, 1.09) | 0.87 (0.60, 1.25) | 0.89 (0.61, 1.31) | 0.69 |
| Multivariate3 | 1 | 0.67 (0.46, 0.99) | 0.75 (0.50, 1.13) | 0.61 (0.39, 0.97) | 0.06 |
| Distal | |||||
| Age-adjusted | 1 | 1.25 (0.69, 2.27) | 1.40 (0.75, 2.61) | 1.18 (0.60, 2.34) | 0.57 |
| Multivariate3 | 1 | 0.82 (0.41, 1.61) | 1.02 (0.50, 2.08) | 0.57 (0.24, 1.34) | 0.34 |
| Rectal | |||||
| Age-adjusted | 1 | 1.05 (0.54, 2.03) | 1.28 (0.69, 2.36) | 0.53 (0.26, 1.07) | 0.14 |
| Multivariate3 | 1 | 0.70 (0.31, 1.59) | 0.93 (0.43, 1.98) | 0.24 (0.09, 0.65) | 0.02 |
| By stage | |||||
| Local/regional | |||||
| Age-adjusted | 1 | 0.90 (0.68, 1.20) | 1.04 (0.77, 1.40) | 0.84 (0.61, 1.15) | 0.41 |
| Multivariate3 | 1 | 0.73 (0.53, 1.01) | 0.86 (0.62, 1.21) | 0.51 (0.35, 0.76) | 0.003 |
| Metastatic | |||||
| Age-adjusted | 1 | 0.90 (0.43, 1.89) | 0.80 (0.38, 1.68) | 0.85 (0.38, 1.94) | 0.63 |
| Multivariate3 | 1 | 0.92 (0.41, 2.08) | 0.87 (0.37, 2.04) | 0.84 (0.32, 2.19) | 0.68 |
1
ORs (95% CIs) for CRC were determined by conditional logistic regression. CRC, colorectal cancer.
2
Medians for each quartile used in the trend test: quartile 1 = 243 μmol/L, quartile 2 = 271 μmol/L, quartile 3 = 295 μmol/L, quartile 4 = 327 μmol/L.
3
Multivariate analyses were adjusted for age, baseline BMI, ever had colonoscopy, smoking, physical activity (min/wk of moderate or strenuous activity), hormone replacement therapy, red blood cell folate, plasma vitamin B-12, and plasma pyridoxal-5′-phosphate.