Table 1.
Characteristics of the study participants. Robertsonian translocation carriers and control donors
| Patient | Translocation | Age | Semen parameters | Result | SCSA | Reproductive history | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Volume (ml) | Concentration (×106/ml) | Motility (%) | Normal morphology (%) | DFI (%) | HDS (%) | |||||
| Group A | ||||||||||
| Rob1a | t(13;14) | 30 | 1.8 | 155 | 50 | 30 | N | 18.2 | 10.4 | 1 SA, 1 ectopic pregnancy–SA |
| Rob2 | t(13;14) | 29 | 1.5 | 28 | 42 | n.a. | N | 12.1 | 22.9 | primary infertility |
| Rob3 | t(13;14) | 34 | 2.3 | 57 | 60 | 23 | N | 10.7 | 12.9 | primary infertility 24 months, 3 IVF-ET sine eff. |
| Rob4a | t(15;22) | 28 | 3.2 | 44 | 50 | 5 | N | 41.8 | 12.3 | primary infertility 5 months,1 IVF-ET sine eff. |
| Mean ± SD | 30.3 ± 2.6 | 2.2 ± 0.7 | 71.0 ± 57.2 | 50.5 ± 11.7 | 19.3 ± 12.9 | 20.7 ± 14.4 | 14.6 ± 5.6 | |||
| Group B | ||||||||||
| Rob5 | t(13;14) | 31 | 7.4 | 8 | 60 | 9 | O | 36.5 | 36.4 | 1 SA, 1 ITP for malformations |
| Rob6 | t(13;14) | 39 | 4.6 | 0.3 | 40 | n.a. | O | 35.5 | 28.8 | primary infertility 48 months |
| Rob7 | t(13;14) | 40 | 2.0 | 9 | 14 | 11 | OA | 31.6 | 20.4 | primary infertility 12 months |
| Rob8 | t(13;14) | 31 | 2.8 | 0.3 | 0 | n.a. | OA | n.a. | n.a. | primary infertility |
| Rob9a | t(13;14) | 27 | 4.3 | 6.7 | 12 | 6 | OA | 23.7 | 29.1 | primary infertility 18 months, 2 IVF-ET sine eff. |
| Rob10 | t(13;14) | 35 | 4.2 | 36 | 40 | 4 | T | 27.0 | 20.5 | primary infertility 48 months |
| Rob11 | t(13;14) | 36 | 2.0 | 5 | 45 | 30 | O | n.a. | n.a. | primary infertility 18 months, 1 IVF-ET sine eff. |
| Rob12 | t(13;14) | 28 | 1.8 | 22 | 6 | 11 | A | 17.8 | 51.4 | primary infertility 48 months |
| Rob13 | t(14;21) | 28 | 4.0 | 4 | 25 | 1 | OAT | 33.6 | 24.4 | primary infertility |
| Mean ± SD | 32.8 ± 4.9 | 3.7 ± 1.8 | 10.1 ± 11.6 | 26.9 ± 20.4 | 10.3 ± 9.4 | 29.4 ± 6.9 | 30.1 ± 10.9 | |||
| Control donorsa | ||||||||||
| C1 | 26 | 7.2 | 134 | 70 | 42 | N | 8.2 | 5.9 | donor | |
| C2 | 29 | 2.3 | 44 | 60 | 26 | N | 6.8 | 5.8 | donor | |
| C3 | 28 | 4.3 | 72 | 50 | 30 | N | 9.4 | 11.0 | donor | |
| C4 | 27 | 3.5 | 120 | 70 | 33 | N | 6.8 | 6.5 | donor | |
| C5 | 27 | 2.4 | 64 | 60 | 27 | N | 8.9 | 8.9 | donor | |
| C6 | 28 | 2.1 | 71 | 60 | 24 | N | 12.7 | 12.8 | donor | |
| C7 | 27 | 3.8 | 36 | 70 | 33 | N | 17.3 | 12.7 | donor | |
| C8 | 29 | 3.2 | 84 | 60 | 27 | N | 15.6 | 12.5 | donor | |
| C9 | 27 | 5.3 | 49 | 60 | 24 | N | 16.7 | 7.2 | donor | |
| C10 | 24 | 4.6 | 53 | 55 | 17 | N | 10.7 | 14.0 | donor | |
| Mean ± SD | 27.2 ± 1.5 | 3.9 ± 1.6 | 72.7 ± 32.2 | 61.5 ± 6.7 | 28.3 ± 6.7 | 11.3 ± 4.0 | 9.7 ± 3.2 | |||
Group A–Robertsonian translocation, normospermic; Group B–Robertsonian translocation, abnormal semen
a[53]
n.a. not analysed; N normospermic; O oligospermic; A asthenospermic; T teratospermic
SA spontaneous abortion; ITP induced termination of pregnancy; IVF-ET in vitro fertilization cycle with embryotransfer