Table 2.
Characteristics of the study participants. Reciprocal translocation carriers
| Patient | Translocation | Age | Semen parameters | Result | SCSA | Reproductive history | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Volume (ml) | Concentration (×106/ml) | Motility (%) | Normal morphology (%) | DFI (%) | HDS (%) | |||||
| Group C | ||||||||||
| Rec1 | t(1;2) | 30 | 2.0 | 18 | 55 | 20 | N | 10.2 | 14.2 | primary infertility, 1 IVF-ET→SA |
| Rec2 | t(1;6) | 46 | 2.0 | 125 | 61 | 12 | N | n.a. | n.a. | 1 missed abort, 2 IUI sine eff., 1 IVF/PGD-ET→a girl 46,XX |
| Rec3 | t(2;7) | 30 | 4.2 | 36 | 70 | 12 | N | 12.3 | 8.8 | 1 IVF/PGD-ET→twins 46,XX |
| Rec4 | t(3;4) | 30 | 3.8 | 51 | 78 | 10 | N | 30.7 | 1.2 | primary infertility 18 months |
| Rec5 | t(3;5) | 30 | 3.2 | 36 | 68 | 19 | N | 15.4 | 9.6 | a boy 46,XY,t(3;5)pat |
| Rec6 | t(4;7) | 36 | 4.1 | 37 | 45 | 28 | N | 19.3 | 11.8 | primary infertility 36 months |
| Rec7a | t(4;7) | 38 | 5.8 | 69.5 | 63 | 19.5 | N | 6.9 | 6.8 | |
| Rec8 | t(4;8) | 36 | 3.1 | 81 | 70 | 28 | N | 9.6 | 10.9 | a girl 46,XX, 1 ITP for 46,XX,der(4)pat |
| Rec9 | t(4;11) | 23 | 1.8 | 120 | 50 | 20 | N | 69.0 | 54.9 | 1 SA, secondary infertility 18 months, spontaneous gravidity |
| Rec10 | t(4;16) | 33 | 2.5 | 76.7 | 51 | 15 | N | 32.7 | 12.8 | primary infertility 12 months |
| Rec11 | t(5;9) | 33 | 3.6 | 196 | 70 | 35 | N | 8.3 | 8.6 | primary infertility |
| Rec12 | t(5;19) | 33 | 1.7 | 85 | 70 | 23 | N | 7.1 | 7.2 | a boy 46,XY,t(5;19)pat |
| Rec13a | t(6;7) | 34 | 1.6 | 156 | 65 | 10.5 | N | 21.0 | 13.3 | a boy 46,XY,der(7)pat, 1 ITP for 46,XY,der(7)pat |
| Rec14 | t(6;14) | 30 | 4.2 | 116 | 55 | 7 | N | 9.4 | 8.4 | 1 ITP, 1 missed abort |
| Rec15 | t(7;9) | 27 | 3.0 | 60 | 60 | 50 | N | 9.2 | 13.6 | primary infertility |
| Rec16 | t(7;10) | 31 | 2.1 | 76 | 45 | 11 | N | 30.0 | 12.2 | primary infertility |
| Rec17a,b | t(7;10) | 28 | 4.0 | 63 | 65 | 12 | N | 14.6 | 11.9 | 2 ITP for 46,XX,der(7)pat; 2 IVF-ET→a healthy girl |
| Rec18 | t(7;12) | 28 | 2.0 | 303 | 75 | 16 | N | 6.9 | 12.7 | 3 IVF/PGD-ET sine eff. |
| Rec19c | t(10;15) | 30 | n.a. | 29 | 75 | 21 | N | 56.8 | 29.5 | 1 SA, 1 IVF-ET sine eff., 2 IVF/PGD-ET sine eff. |
| Rec20a,d | t(11;18) | 27 | 3.8 | 60 | 60 | 34 | N | 8.1 | 11.0 | 1 SA, secondary infertility |
| Rec21a,d | t(11;18) | 53 | 2.5 | 84 | 50 | 18 | N | 56.5 | 4.2 | 1 SA, a son 46,XY, a son 46,XY, t(11;18)pat |
| Rec22a | t(13;15) | 38 | 4.5 | 145 | 60 | 39 | N | 8.2 | 3.9 | 3 SA, 3 IVF-ET sine eff. |
| Mean ± SD | 32.9 ± 6.6 | 3.1 ± 1.1 | 92.0 ± 65.2 | 61.9 ± 9.8 | 20.9 ± 10.9 | 21.1 ± 18.6 | 12.7 ± 11.1 | |||
| Group D | ||||||||||
| Rec23 | t(1;2) | 30 | 4.0 | 9 | 20 | 16 | OA | 1.8 | 11.6 | 2 IVF/PGD-ET sine eff. |
| Rec24 | t(1;7) | 28 | 2.2 | 1 | 5 | 20 | OA | n.a. | n.a. | primary infertility 18 months, 1 IVF-ET sine eff. |
| Rec25 | t(1;13) | 33 | 3.0 | 18 | 33 | 12 | A | 21.9 | 16.3 | 1 IVF/PGD-ET sine eff. |
| Rec26 | t(1;14) | 29 | 3.0 | 19 | 10 | 10 | A | 54.2 | 19.9 | 3 IVF/PGD-ET→a boy 46,XY |
| Rec27 | t(2;7) | 30 | 2.0 | 12 | 8 | n.a. | OA | 40.7 | 42.0 | primary infertility 30 months, 3 IVF/PGD-2 ET sine eff. |
| Rec28 | t(2;7) | 33 | 4.5 | 29 | 31 | 16 | A | 37.9 | 19.0 | 1 IVF/PGD-ET sine eff. |
| Rec29 | t(4;6) | 30 | 3.0 | 34 | 26 | 6 | A | 13.4 | 53.8 | 2 ITP for malformations, 2 IVF/PGD-ET→a boy 46,XY |
| Rec30a | t(4;10) | 30 | 6.5 | 37 | 35 | 13 | A | 18.3 | 22.5 | primary infertility 18 months, 2 IVF-ET sine eff. |
| Rec31 | t(5;15) | 34 | 2.0 | 72 | 47 | 4 | T | 11.8 | 20.2 | a son 46,XY,der(15)pat, 2 IVF-ET→ITP unbalanced karyotype |
| Rec32a,b | t(7;10) | 25 | 5.7 | 76 | 50 | 3 | T | n.a. | n.a. | |
| Rec33a | t(7;13) | 29 | 7.5 | 76 | 55 | 3 | T | 34.3 | 14.9 | primary infertility 6 years |
| Rec34 | t(8;13) | 29 | 4.0 | 7 | 30 | 21 | OA | 41.8 | 10.5 | primary infertility 48 months, 1 IVF-ET sine eff. |
| Rec35 | t(11;22) | 28 | 6.2 | 10 | 34 | 8 | OA | 31.6 | 21.0 | primary infertility 24 months, 2 IVF/PGD-ET sine eff. |
| Rec36 | t(13;15) | 35 | 4.6 | 21 | 20 | 2 | AT | 29.5 | 20.2 | |
| Rec37 | t(16;17) | 38 | 4.5 | 17 | 45 | 3 | T | n.a. | n.a. | primary infertility 12 months |
| Mean ± SD | 30.7 ± 3.3 | 4.2 ± 1.7 | 29.2 ± 25.5 | 29.9 ± 15.4 | 9.8 ± 6.6 | 28.1 ± 15.0 | 22.7 ± 12.6 | |||
Group C–reciprocal translocation, normospermic; Group D–reciprocal translocation, abnormal semen
n.a. not analysed; N normospermic; O oligospermic; A asthenospermic; T teratospermic
IVF in vitro fertilization cycle; PGD preimplantation genetic diagnosis; ET embryotransfer; SA spontaneous abortion; IUI intrauterine insemination; ITP induced termination of pregnancy