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. 2013 Mar 15;27(4):598–605. doi: 10.1210/me.2012-1371

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Copyright © 2013 by The Endocrine Society

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Kiss1^Lrh1^−/− Mice Have Abnormal Follicles. A and B, Serum LH (A) and FSH (B) levels in female Lrh1^fl/fl (fl/fl) and Lrh1^Kiss1^−/− knockout (KO) mice in diestrus or estrus (n = 5–8 per group). C, Serum FSH and LH levels in female control and kisspeptin neuron-specific Lrh1-Tg mice in diestrus (n = 4 per group). D, Hematoxylin and eosin staining of ovaries (Ov) from fl/fl and KO mice in diestrus or estrus as indicated. 100× magnification, 5-μm sections, scale bars = 100 μm. cl, corpora lutea; g, graafian follicle; cy, follicular cyst. Quantification of follicular cysts (panel E) and corpora lutea (panel F) in ovaries from fl/fl and KO mice (n = sections from 5–8 mice per group). G, Quantification of corpora lutea in superovulated fl/fl and KO mice (n = sections from 3–7 mice per group). H, Plasma E₂ concentrations in fl/fl and KO mice in diestrus or estrus (n = 5–8 mice per group). Error bars represent SEM. Student's t test: a = P < .05.