Table 2.
Top 25 Genotyped SNPs Most Highly Associated with Plasma E2 Concentrations
| SNP | Chr | bp Positiona | Effectb | Lower 95% CI | Upper 95% CI | P Value | MAF |
|---|---|---|---|---|---|---|---|
| rs1864729 | 8 | 98 351 365 | 1.589 | 1.350 | 1.871 | 3.49E-08 | 0.098 |
| rs2567769 | 8 | 98 367 024 | 1.581 | 1.341 | 1.864 | 6.49E-08 | 0.087 |
| rs11688246 | 2 | 85 559 188 | 1.832 | 1.469 | 2.285 | 1.04E-07 | 0.052 |
| rs4902141 | 14 | 62 038 148 | 2.161 | 1.629 | 2.867 | 1.23E-07 | 0.026 |
| rs12565140 | 1 | 33 701 345 | 1.425 | 1.247 | 1.629 | 2.52E-07 | 0.136 |
| rs2567768 | 8 | 98 372 327 | 1.532 | 1.305 | 1.800 | 2.61E-07 | 0.098 |
| rs12118390 | 1 | 80 683 702 | 2.253 | 1.658 | 3.060 | 2.62E-07 | 0.022 |
| rs4699587 | 4 | 95 834 792 | 1.763 | 1.416 | 2.194 | 4.79E-07 | 0.048 |
| rs16906958 | 8 | 80 683 200 | 1.857 | 1.461 | 2.361 | 5.38E-07 | 0.043 |
| rs7072122 | 10 | 44 354 678 | 1.730 | 1.397 | 2.141 | 6.03E-07 | 0.051 |
| rs4761470 | 12 | 93 207 335 | 1.375 | 1.214 | 1.556 | 6.14E-07 | 0.177 |
| rs10515260 | 5 | 97 102 304 | 1.913 | 1.485 | 2.463 | 6.34E-07 | 0.035 |
| rs11107531 | 12 | 93 325 452 | 1.328 | 1.187 | 1.485 | 8.31E-07 | 0.243 |
| rs17339671 | 4 | 95 832 198 | 1.467 | 1.259 | 1.709 | 1.14E-06 | 0.107 |
| rs16832889 | 3 | 183 333 978 | 3.085 | 1.965 | 4.844 | 1.20E-06 | 0.011 |
| rs17042688 | 2 | 52 365 298 | 1.911 | 1.474 | 2.476 | 1.20E-06 | 0.038 |
| rs10501858 | 11 | 125 535 825 | 1.539 | 1.295 | 1.829 | 1.24E-06 | 0.091 |
| rs1953248 | 14 | 62 192 760 | 1.613 | 1.331 | 1.953 | 1.25E-06 | 0.073 |
| rs12620464 | 2 | 101 396 078 | 1.397 | 1.221 | 1.597 | 1.29E-06 | 0.143 |
| rs12475021 | 2 | 52 388 911 | 1.917 | 1.476 | 2.492 | 1.36E-06 | 0.037 |
| rs6077414 | 20 | 8 652 552 | 1.466 | 1.257 | 1.711 | 1.41E-06 | 0.092 |
| rs478665 | 1 | 65 288 121 | 1.772 | 1.407 | 2.233 | 1.45E-06 | 0.050 |
| rs727333 | 21 | 40 624 817 | 1.542 | 1.295 | 1.837 | 1.47E-06 | 0.081 |
| rs724767 | 3 | 195 205 024 | 1.436 | 1.241 | 1.663 | 1.52E-06 | 0.115 |
| rs11548323 | 1 | 27 604 238 | 1.396 | 1.219 | 1.598 | 1.70E-06 | 0.170 |
Bold face, are the three SNPs in or near the TSPYL5 gene.