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GPCR ubiquitin-dependent and ubiquitin-independent MVB sorting: ubiquitin targets agonist-activated GPCRs to lysosomes for degradation via the highly conserved ESCRT machinery. However, several GPCRs that are not ubiquitinated have been shown to sort to lysosomes independent of ubiquitination. The adaptor protein ALIX links the GPCR to ESCRT III and facilitates sorting to MVB/lysosomes. Ub, ubiquitin.
