Figure 1.

The CTL inducing activities of the nanoparticles. The nanoparticles containing OVA only (NP [OVA]), both OVA and poly-IC (NP [OVA+I:C], or both OVA and CpG ODN (NP[OVA+CpG]) were injected intravenously into tail veins of mice. Seven days later, an in vivo CTL assay was performed in the mice using CFSE-labeled syngeneic target cells. (A) Representative histograms of the slpeen cells of individual mice were shown. The percentages of specific killing of OVA[257-264] peptide-pulsed target cells in the spleens (B) and lymph nodes (C) were graphically represented.