Table 1.

Hypothetical Over- and Undertreatment With Different Management Strategies For cN0 OSCC

cN0 Management	No. of Surgical Procedures	Per 100 cN0 Patients
		pN0 Undergoing Neck Dissection	pN+ Without Neck Dissection
Watchful waiting	One	0	30
Elective neck dissection	One	70	0
Sentinel mapping (IHC)17*	Two (if N+)	0	3
Sentinel mapping (PCR)18†	One	5	4
Microarray12‡	Two	41	4

NOTE. Based on 30% of cN0 as pN+.

Abbreviations: cN0, clinical stage N0; IHC, immunohistochemistry; OSCC, oral squamous cell cancer; N+, node positive; NPV, negative predictive value; PCR, polymerase chain reaction; pN+, nodal metastasis found by pathology.

^*Based on 96% NPV for step-sectioning and IHC, and assuming no false-positive pathology reports.

^†Based on 86% sensitivity and 93.3% specificity for PCR compared with consensus pathology.

^‡Based on Figure 3B; only one surgery would be required if microarray technology can be adapted to biopsy specimens.