Fig. 1.

Differential dosing strategies are an example of chronopharmacological treatment. The dosage of drugs can be adjusted to correspond with times of greatest disease severity or susceptibility. The figure on top (a) includes a solid line that depicts variations in plasma levels of antiepileptic medication in individuals who received a higher evening dose of carbamazepine, as ascertained by computer generated pharmacokinetic modeling (solid line). The figure below (b) illustrates the percentage distribution of frontal lobe seizures over a 24-hour period, as demonstrated in a series of 41 consecutive pediatric patients. Figure modified and adapted with permission from Guilhoto et al. 2011. [8••]