Table 3.
Positive rate of patients with different tumor-related factors in four α-fetoprotein level inervals n (%)
| Variables AFP (μg/L) | ≤ 20 | 20-400 | 401-800 | ≥ 801 | n = 2304 | P value |
| HBV infection | < 0.001 | |||||
| Yes | 507 (26.7) | 441 (23.2) | 126 (6.4) | 801 (42.4) | 1875 (81.4) | |
| No | 202 (47.0) | 82 (19.2) | 18 (4.3) | 127 (29.5) | 429 (18.6) | |
| Tumor size (cm) | < 0.001 | |||||
| ≤ 5 | 243 (27.90) | 361 (41.45) | 66 (7.58) | 201 (23.08) | 871 (37.80) | |
| 5-10 | 262 (32.59) | 206 (25.62) | 43 (5.35) | 293 (36.44) | 804 (34.90) | |
| ≥ 10 | 117 (18.60) | 84 (13.35) | 27 (4.29) | 401 (63.75) | 629 (27.30) | |
| Tumor number | 0.593 | |||||
| 1 | 469 (28.15) | 461 (27.67) | 103 (6.18) | 622 (38.00) | 1666 (72.31) | |
| 2 | 66 (22.92) | 97 (33.68) | 14 (4.86) | 111 (38.54) | 288 (12.50) | |
| ≥ 3 | 87 (24.86) | 93 (26.57) | 19 (5.43) | 151 (43.14) | 350 (15.19) | |
| Vascular invasion | < 0.001 | |||||
| No | 510 (29.75) | 498 (29.05) | 101 (5.89) | 605 (35.30) | 1714 (74.39) | |
| Yes | 112 (19.98) | 153 (25.93) | 35 (5.93) | 290 (49.15) | 590 (25.61) | |
| Tumor differentiation | 0.012 | |||||
| High | 57 (42.22) | 60 (44.44) | 5 (3.70) | 16 (11.85) | 135 (5.99) | |
| Intermediate | 285 (29.75) | 263 (27.45) | 81 (8.46) | 335 (34.97) | 958 (41.84) | |
| Low | 263 (35.93) | 134 (18.31) | 43 (5.87) | 301 (41.12) | 732 (32.16) | |
| TNM staging | 0.767 | |||||
| I | 125 (25.25) | 139 (28.08) | 23 (4.65) | 208 (42.02) | 495 (21.48) | |
| II | 90 (31.14) | 81 (28.03) | 18 (6.23) | 100 (34.60) | 289 (12.54) | |
| IIIA | 197 (27.13) | 201 (27.69) | 50 (6.89) | 278 (38.29) | 726 (31.51) | |
| IIIB | 50 (28.36) | 64 (29.91) | 10 (4.67) | 90 (42.06) | 214 (9.29) | |
| IIIC | 27 (26.73) | 28 (27.72) | 5 (4.95) | 41 (40.59) | 101 (4.38) | |
| IV | 133 (27.77) | 138 (28.81) | 30 (6.26) | 178 (37.16) | 479 (20.79) | |
| BCLC staging | < 0.001 | |||||
| A | 261 (30.03) | 266 (30.61) | 56 (6.44) | 286 (32.91) | 869 (37.72) | |
| B | 59 (23.51) | 78 (31.08) | 15 (5.98) | 99 (39.44) | 251 (10.89) | |
| C | 271 (23.36) | 272 (24.46) | 53 (5.16) | 432 (42.02) | 1028 (44.62) | |
| D | 31 (19.87) | 35 (22.44) | 12 (7.69) | 78 (50.00) | 156 (6.77) | |
| China staging | 0.124 | |||||
| I | 34 (24.82) | 54 (39.42) | 3 (2.19) | 46 (33.58) | 137 (5.95) | |
| IIa | 48 (24.24) | 70 (35.35) | 7 (3.54) | 73 (36.87) | 198 (8.59) | |
| IIb | 231 (25.87) | 237 (26.54) | 65 (7.28) | 360 (40.31) | 893 (38.76) | |
| III | 309 (28.72) | 290 (29.95) | 61 (5.67) | 416 (38.66) | 1078 (46.70) |
Patients were divided into four groups according to the serum α-fetoprotein (AFP) level, they were ≤ 20, 20-400, 401-800 and ≥ 801 μg/L, the positive rate of patients in each interval of AFP were calculated. HBV: Hepatitis B virus; TNM: Tumor-node-metastasis; BCLC: The Barcelona-Clinic Liver Cancer Group.