FIGURE 2.

Effects of MG132 treatment on the sodium current properties and mRNA level. (A) Current density-voltage relationship of I_Na in control and mdx^5cv mice treated with MG132 or 0.9% NaCl, as indicated. The protocol is indicated in inset. (B) Bar graph quantifying the amounts of sodium current in control and mdx^5cv ventricular myocytes. Four cells were patched for each mouse and the number of mice used for quantification is indicated in the bars. The “normalized current” represents the maximum current density recorded at a given voltage (-25 mV). (C) Steady-state activation and inactivation curves. The protocol is indicated in inset. The number of mice used for quantification is indicated in the bars. Results are expressed as normalized mean signal intensity. *P < 0.05, n.s. not significant.