Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Apr;141(4):445–465. doi: 10.1085/jgp.201210856

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Kulleperuma et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 1. — A subset of a larger multiple sequence alignment of the four TM regions of VSDs informed by alignment of the open state produced by structural superposition of crystal structures of the paddle chimera (green ribbon) and Na_VAB (white ribbon). The arginines of S4 (blue sticks) are labeled according to their position on the paddle chimera. Note that the most extracellular R of Na_VAB corresponds to R2 of the paddle chimera, and the most intracellular R of Na_VAB corresponds to K5 of the paddle chimera. The completely conserved phenylalanine on S2 is shown and labeled as “CTC.” The following residues are indicated with symbols over the alignment: %, CTC; *, R1 of Shaker; #, R2 of Shaker; ^, R3 of Shaker.