Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Apr;141(4):431–443. doi: 10.1085/jgp.201210942

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Wang et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Repolarization envelopes separate two components of charge moved at 0 mV, but not at +60 mV. (A and B) Illustrative currents obtained using an envelope of tails protocol. Membrane potential was stepped to 0 mV from −100 mV for varying durations of time (A, 1-ms intervals; B, 10-ms intervals) and repolarized back to −100 mV. Note that for shorter pulses, Ig_off decay was best fitted with a single exponential, whereas longer pulses led to the appearance of a second, slower component (highlighted with arrows; time constants obtained using single or double exponentials are shown). (C and D) Q_on and Q_off for pulses to 0 mV from integration of current tracings in A and B. Note Q_off increase after depolarizing pulses longer than ∼20 ms. (E) Time constants for saturation of fast and slow phases of Q_off after pulses to 0 mV. (F) Change in Q_on/Q_off ratio for pulses to 0 mV of increasing duration. (G–J) Same experiments as in A–F, but depolarizing pulses were to +60 mV.