Figure 3.

Predicted median overall survival (OS) versus the observed OS in phase III randomized controlled trials (RCTs) including bortezomib- or lenalidomide-based regimens for the treatment of relapsed/refractory multiple myeloma. Horizontal lines represent estimated 95% confidence intervals (CIs) for the median OS based on the modeled median time-dependent endpoints from each study arm. Solid circle represents observed median OS contained in the corresponding 95% CI estimate, and lozenges represent the observed median OS not contained in the corresponding 95% CI estimate. Where data are from different studies, a direct comparison is not possible as different studies use different patient populations, different study designs, and were conducted at different time points. Vertical dashed line stands for the mean of median OS of the Dex arms. Abbreviations: Bort, bortezomib; Dex, dexamethasone; Len, lenalidomide; PLD, pegylated liposomal doxorubicin.