Table 1.

Body weight before and after intervention, and tibialis anterior, extensor digitorum longus, gastrocnemius, soleus and plantaris muscle weights on the left and right sides for sham-operated control animals and animals exposed to the ICU intervention for 0.25–4 days, 5–8 days and 9–14 days

	BW (g)		TA (mg)		EDL (mg)		Gast (mg)		SOL (mg)		PL (mg)
Duration	pre	post	left	right	left	right	left	right	left	right	left	right
Controls1 (n= 12)	311 ± 26	311 ± 26	555 ± 47	560 ± 56	144 ± 10	144 ± 11	1652 ± 213	1658 ± 133	126 ± 12	121 ± 20	299 ± 64	323 ± 28
0.25–4 days2 (n= 20)	307 ± 18	307 ± 21	534 ± 53	519 ± 44*	132 ± 11	133 ± 17	1545 ± 111	1503 ± 116*	119 ± 19	116 ± 18	286 ± 27	279 ± 31
5–8 days3 (n= 3)	281 ± 421,2	235 ± 371,2,*	430 ± 751,2	383 ± 441,2	105 ± 191,2	99 ± 151,2,**	999 ± 1481,2	969 ± 1631,2	87 ± 161,2	79 ± 121,2	215 ± 221,2	205 ± 301,2
9–14 days4 (n= 8)	301 ± 471,2	199 ± 331,2,**	357 ± 861,2	316 ± 961,2,*	98 ± 231,2	81 ± 201,2,***	843 ± 2641,2	770 ± 2321,2,**	93 ± 211,2	68 ± 181,2,**	163 ± 351,2	146 ± 351,2,***
P	<0.001		<0.001		<0.001		<0.001		0.001		0.001

BW, body weight; TA, tibialis anterior; EDL, extensor digitorum longus; GAST, gastrocnemius; SOL, soleus; PL, plantaris. Significant differences between groups are presented as superscripts and between loaded and unloaded side as asterisks (*P < 0.05, **P < 0.01, ***P < 0.001). Values are means ± SD.