Table 1.
Summary of the genes and their functional categories
| Biological function | Genesa | |
|---|---|---|
|
Prp(Sc replication and accumulation |
|
A2M, ABCA1, ADAMTS1, APOD, PTGS1, SERPING1 |
|
Immune response |
|
|
| |
Complement activation: complement system |
C3 |
| |
Complement activation: coagulation & kallikrein system |
PDPN, PROS1 |
| |
Pattern recognition and other receptor |
CD14, CD68, ITGB2, FCGR2B, TREM2, TLR2 |
| |
Microglia/astrocyte activation related |
GFAP, PTPN6, STAT1, STAT3, THBS2, TNFRSF1A, VIM |
| |
Cytokine, chemokine and growth factor related |
CSF1, CSF1R, CXCL10, CX3CR1 |
| |
Leukocyte extravasation |
CYBB, ITGAX, NCF1, TGFB1, TGFBR1, TGFBR2 |
| |
Other immune response |
AIF1, B2M, CD83, CD86, CEBPA, CEBPD, Ctla2a, HLA-E, IFI27, IFIT3, NFATC1, SBNO2 |
|
Cell death |
|
CASP1, CCN D1, CLU, HSPB1, HSPB8, ID3, MCL1, RBP1, SOCS3, TGM2 |
| Other | ALOX5AP, CD9, FLI1, GUSB, HPGD, IL13RA1, INPP5D, ISG15, LCN2, LGAL53, LXN, MET, OSMR, P2RX7, S100A4, SOX9, SRGN, SYNPO, TF |
aGenes in the SCC are indicated in bold.