Table 1.
Physicochemical characteristics of the roxithromycin nanoparticles
| Sample | RXN-PLGA (mg) | Mean diameter ± SD (nm) | PDI ± SD | Zeta potential ± SD (mV) | Drug loading (%) | Entrapment efficiency (%) |
|---|---|---|---|---|---|---|
|
S1 |
4 -25 |
152±8.4 |
0.09±0.10 |
-1.88±0.72 |
8.8±1.3 |
64.0±4.2 |
|
S2 |
5 -25 |
178±6.3 |
0.13±0.03 |
-2.63±0.53 |
10.5±1.1 |
73.0±3.8 |
|
S3 |
8.2- 25 |
196±10.5 |
0.11±0.05 |
-6.23±2.10 |
13.0±1.0 |
80.0±6.5 |
|
S4 |
10 -20 |
177±6.7 |
0.09±0.05 |
-2.48±0.36 |
11.0±2.1 |
34.0±5.5 |
| S5 | 10- 10 | 181±11.6 | 0.93±0.12 | -4.02±1.64 | 12.5±1.8 | 41.0±4.3 |