Fig. 6.

Extended Aurora A interaction network. Schematic indicates proteins that known or highly likely to interact physically and/or functionally (indirect interaction) with Aurora A/AURKA. All proteins are indicated by official gene symbol. Interaction data were collected using online databases String [251] (using medium confidence score 0.4 and excluding text-mining-only results) and Ingenuity [http://www.ingenuity.com/] (extracting only experimental and high confidence predicted interactions). Data were imported, merged, and visualized in Cytoscape [252]. Blue rim around protein indicates direct protein–protein interaction; lack of rim indicates indirect interaction. Green circles represent highly validated interactions generally reported in publications. Blue circles represent high confidence hits from larger screens, but are less well studied. Green lines indicate interactions with Aurora A/AURKA; blue lines indicate interactions among proteins described as interacting with Aurora A/AURKA