FIG. 2.

High endothelial venules, and CCL21 and CXCL13 expression in LM tertiary lymphoid organs. (A) and (B) PNAd-positive high endothelial venules (HEV) in lymphoid aggregates from two microcystic LM of the tongue. (C) A lymphoid aggregate in a microcystic LM of the neck with PNAd-positive HEVs. (D) The T-cell homing chemokine CCL21 is detected in the same lymphoid aggregate, in stromal cells closely associated with HEV. (E) CCL21 expression is widespread in lymphoid aggregates in this patient's LM. (F) The B-cell homing chemokine CXCL13 also can be detected in multiple lymphoid aggregates in the same LM from this patient. Scale bar = 100 microns. This figure is available in color in the online version of this article at www.liebertpub.com/lrb