Table 4.
Baseline lung function (FEV1) and LTB4R SNPs in the adult asthma cohort
| SNP | MAF | p-value (R2) | Group (n) | Value, % (Mean ± SEM) |
|---|---|---|---|---|
|
LTB4R2 |
|
|
|
|
| *rs2332320 |
0.10 |
0.703 |
0 (210) |
92.568 ± 1.424 |
| (5′UTR) |
|
(0.001) |
1 (50) |
91.331 ± 2.918 |
| rs11158635 |
0.19 |
0.421 |
0 (168) |
93.592 ± 1.599 |
| (5′UTR) |
|
(0.007) |
1 (79) |
90.047 ± 2.331 |
| |
|
|
2 (11) |
89.882 ± 6.247 |
| rs2516564 |
0.19 |
0.422 |
0 (170) |
93.529 ± 1.592 |
| (5′UTR) |
|
(0.007) |
1 (77) |
89.871 ± 2.365 |
| |
|
|
2 (10) |
90.412 ± 6.564 |
|
LTB4R1 |
|
|
|
|
| rs2224122 |
0.20 |
0.599 |
0 (166) |
93.469 ± 1.588 |
| (5′UTR) |
|
(0.004) |
1 (81) |
90.802 ± 2.274 |
| |
|
|
2 (12) |
90.642 ± 5.907 |
| rs1046587 |
0.49 |
0.761 |
0 (73) |
90.804 ± 2.436 |
| (3′UTR) |
|
(0.002) |
1 (118) |
92.044 ± 1.916 |
| |
|
|
2 (67) |
93.409 ± 2.543 |
| rs3181384 |
0.20 |
0.694 |
0 (167) |
93.157 ± 1.598 |
| (3′UTR) |
|
(0.003) |
1 (82) |
90.917 ± 2.281 |
| 2 (12) | 90.642 ± 5.962 |
Regression analysis was used to investigate the association between LTB4R SNPs and baseline percent predicted FEV1 in the Adult Asthma Cohort (n=299) using the additive model. 0, 1, 2 represent number of genotypes for major, heterozygotes and minor genotypes respectively. *Dominant model analysis was completed for rs2332320 due to low number of minor allele homozygotes in the additive model.