Table 1.
Details of the analyzed animals used in immunohistochemistry (IHC), quantitative real-time PCR (qRT-PCR) or Western/dot blot
| Animals | Age (years) | Symptomatic status | IHC | qRT-PCR | Western/dot blot |
|---|---|---|---|---|---|
| Ctrl1 |
6.5 |
Ctrl |
✓ |
✓ |
- |
| Ctrl2 |
6 |
Ctrl |
✓ |
✓ |
- |
| Ctrl3 |
9 |
Ctrl |
✓ |
✓ |
✓ |
| Ctrl4 |
10 |
Ctrl |
✓ |
✓ |
✓ |
| Ctrl5 |
3 |
Ctrl |
✓ |
✓ |
✓ |
| Ctrl6 |
5.5 |
Ctrl |
✓ |
✓ |
✓ |
| Ctrl7 |
4.5 |
Ctrl |
- |
✓ |
- |
| Ctrl8 |
4.5 |
Ctrl |
- |
✓ |
- |
| Ctrl9 |
4.5 |
Ctrl |
- |
✓ |
- |
| Ctrl10 |
1.5 |
Ctrl |
- |
✓ |
- |
| Ctrl11 |
2.5 |
Ctrl |
- |
✓ |
- |
| SC1 |
3.5 |
PC |
✓ |
✓ |
✓ |
| SC2 |
1.5 |
PC |
✓ |
✓ |
✓ |
| SC3 |
4.5 |
PC |
✓ |
✓ |
✓ |
| SC4 |
1 |
PC |
✓ |
✓ |
✓ |
| SC5 |
1.5 |
PC |
- |
✓ |
- |
| SC6 |
5.5 |
C |
✓ |
- |
- |
| SC7 |
6.5 |
C |
✓ |
- |
- |
| SC8 |
5 |
C |
✓ |
✓ |
- |
| SC9 |
2.5 |
C |
✓ |
✓ |
✓ |
| SC10 |
4 |
C |
✓ |
✓ |
✓ |
| SC11 |
5.6 |
C |
✓ |
✓ |
✓ |
| SC12 |
7 |
C |
✓ |
✓ |
✓ |
| SC13 |
3.5 |
C |
- |
✓ |
- |
| SC14 |
4 |
C |
- |
✓ |
- |
| SC15 |
4.5 |
C |
- |
✓ |
- |
| SC16 |
4 |
C |
- |
✓ |
- |
| SC17 | 2 | C | - | ✓ | - |
Clinical status of each animal is described: control (Ctrl), preclinical (PC) or clinical (C).