Table 1.
Categories over-represented among the EGF regulated genes
| Term | Count | PValue |
|---|---|---|
|
1 h UP |
||
| Dual specificity protein phosphatase |
5 |
7.42E-08 |
| MAP kinase phosphatase |
5 |
4.38E-07 |
| regulation of cell proliferation |
22 |
1.03E-06 |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
5 |
2.34E-06 |
| regulation of transcription from RNA polymerase II promoter |
20 |
4.92E-06 |
| Cell cycle control |
14 |
6.27E-06 |
| regulation of apoptosis |
20 |
2.05E-05 |
| Rhodanese-like |
5 |
2.06E-05 |
| nuclear lumen |
24 |
2.14E-05 |
| Cell proliferation and differentiation |
21 |
2.19E-05 |
| Basic-leucine zipper (bZIP) transcription factor |
6 |
3.16E-05 |
| organelle lumen |
27 |
3.32E-05 |
| vasculature development |
11 |
3.44E-05 |
| response to organic substance |
18 |
6.09E-05 |
| JNK cascade |
6 |
8.69E-05 |
|
4 h UP |
||
| regulation of cell proliferation |
46 |
4.29E-15 |
| regulation of cell motion |
22 |
1.30E-12 |
| plasma membrane part |
68 |
8.83E-12 |
| cell adhesion |
25 |
1.25E-10 |
| vasculature development |
22 |
1.97E-10 |
| plasma membrane |
91 |
2.71E-10 |
| Focal adhesion |
23 |
2.71E-10 |
| extracellular region part |
40 |
2.87E-10 |
| signal |
75 |
1.24E-09 |
| basement membrane |
12 |
6.78E-09 |
| response to wounding |
29 |
6.99E-09 |
| Signal transduction |
85 |
7.80E-09 |
| integrin binding |
11 |
9.78E-09 |
|
24 h UP |
||
| Dual specificity protein phosphatase |
4 |
1.07E-05 |
| Secreted |
26 |
2.04E-05 |
| wound healing |
10 |
2.17E-05 |
| angiogenesis |
9 |
2.37E-05 |
| ectoderm development |
10 |
3.00E-05 |
| disulfide bond |
36 |
3.23E-05 |
| EGF-like region, conserved site |
11 |
3.30E-05 |
| MAP kinase phosphatase |
4 |
3.62E-05 |
| heparin-binding |
6 |
4.53E-05 |
| regulation of cell migration |
9 |
6.13E-05 |
| extracellular region part |
19 |
7.79E-05 |
| Skin |
26 |
1.11E-04 |
| epidermis development |
9 |
1.11E-04 |
| signal |
37 |
1.25E-04 |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
4 |
1.43E-04 |
| regulation of cell proliferation |
18 |
1.57E-04 |
| Pathways in cancer |
13 |
1.79E-04 |
|
48 h UP |
||
| Metallothionein |
8 |
1.21E-12 |
| acetylated amino end |
13 |
2.39E-11 |
| 16q13 |
8 |
5.32E-10 |
| acetylation |
47 |
1.11E-07 |
| Keratinocyte |
11 |
1.35E-07 |
| response to protein stimulus |
9 |
1.08E-05 |
| peptide cross-linking |
5 |
1.16E-04 |
| Cajal-Retzius cell |
9 |
2.25E-04 |
| Chaperone |
8 |
2.75E-04 |
| Steroid biosynthesis |
5 |
2.81E-04 |
| 1q21 |
5 |
3.43E-04 |
| Kidney |
26 |
5.22E-04 |
| abdominal aortic aneurysm |
5 |
8.75E-04 |
|
1 h DOWN |
||
| glycoprotein |
81 |
8.14E-11 |
| signal |
67 |
2.24E-10 |
| plasma membrane part |
56 |
1.11E-09 |
| disulfide bond |
59 |
1.15E-08 |
| Secreted |
37 |
2.93E-06 |
| calcium binding |
8 |
5.58E-05 |
| extracellular region part |
26 |
5.75E-05 |
| regulation of cell motion |
11 |
1.41E-04 |
| Cell adhesion |
19 |
1.62E-04 |
| defense response |
20 |
2.11E-04 |
| calcium |
20 |
2.27E-04 |
| Keratinocyte |
8 |
2.57E-04 |
| sialic acid |
4 |
4.26E-04 |
| disease mutation |
30 |
4.71E-04 |
| Cell junction protein |
7 |
7.65E-04 |
| response to wounding |
17 |
8.70E-04 |
| apical part of cell |
9 |
9.02E-04 |
|
4 h DOWN |
||
| Ichthyosis |
7 |
3.02E-08 |
| epidermis development |
12 |
2.90E-07 |
| epithelial cell differentiation |
9 |
1.55E-05 |
| cell cycle |
12 |
1.71E-04 |
| Keratinocyte |
7 |
1.95E-04 |
| Metabolism of xenobiotics by cytochrome P450 |
6 |
2.24E-04 |
| epidermal cell differentiation |
6 |
2.94E-04 |
| Foreskin |
5 |
4.58E-04 |
| microsome |
6 |
5.75E-04 |
| S100/CaBP-9 k-type, calcium binding |
4 |
9.73E-04 |
| disease mutation |
22 |
9.98E-04 |
|
24 h DOWN |
||
| Intermediate filament |
7 |
2.11E-06 |
| Insulin-like growth factor binding protein, N-terminal |
4 |
3.13E-05 |
| disease mutation |
21 |
6.00E-05 |
| Thyroglobulin type-1 |
4 |
9.49E-05 |
| Structural protein |
9 |
1.06E-04 |
| response to abiotic stimulus |
11 |
1.11E-04 |
| epidermis development |
8 |
1.67E-04 |
| Aldehyde dehydrogenase NAD(P)-dependent |
3 |
1.68E-04 |
| desmosome |
4 |
1.82E-04 |
| response to steroid hormone stimulus |
8 |
2.17E-04 |
| signal |
30 |
4.98E-04 |
| Desmosomal cadherin |
3 |
5.82E-04 |
| response to organic substance |
14 |
5.96E-04 |
| keratin |
6 |
6.72E-04 |
|
48 h DOWN |
||
| phosphoprotein |
120 |
2.06E-10 |
| response to organic substance |
33 |
1.73E-09 |
| response to endogenous stimulus |
24 |
4.75E-09 |
| regulation of programmed cell death |
34 |
8.33E-09 |
| Cell cycle control |
23 |
1.43E-08 |
| response to steroid hormone stimulus |
16 |
4.35E-08 |
| negative regulation of apoptosis |
21 |
5.63E-08 |
| response to hormone stimulus |
21 |
1.02E-07 |
| apicolateral plasma membrane |
11 |
2.74E-07 |
| Desmosomal cadherin |
5 |
5.95E-07 |
| response to wounding |
23 |
2.37E-06 |
| acetylation |
52 |
5.00E-06 |
| response to extracellular stimulus |
14 |
8.15E-06 |
| response to glucocorticoid stimulus |
9 |
9.28E-06 |
| regulation of cell growth |
13 |
1.16E-05 |
| response to nutrient | 11 | 1.83E-05 |
Selected categories from DAVID analysis are presented, sorted from the best p-values from each set. UP denotes induced by EGF, DOWN suppressed. Count gives the number of regulated genes in each category.