Table 4.
Biological processes common in the EGF-, EphrinAs- and SP600125-regulated genes
| Gene ontology: Biological process | EGF 1&4 h UP | SP 1&4 h DN | EFNAs DN |
|---|---|---|---|
| biological process |
3.94E-07 |
9.37E-02 |
6.92E-03 |
| signal transduction |
1.65E-05 |
1.75E-03 |
1 |
| cell communication |
1.94E-05 |
4.39E-03 |
5.49E-01 |
| response to stress |
6.39E-05 |
1 |
3.67E-02 |
| cell motion |
3.70E-03 |
1 |
3.70E-02 |
| |
EGF 1&4 h DN |
SP 1&4 h UP |
EFNAs UP |
| epidermis development |
8.64E-06 |
1 |
9.39E-09 |
| response to external stimulus |
5.47E-04 |
1.69E-06 |
1 |
| tissue development |
6.50E-04 |
9.01E-02 |
1.52E-05 |
| cell differentiation |
6.90E-04 |
4.87E-06 |
1.80E-07 |
| keratinocyte differentiation |
1.42E-02 |
3.14E-01 |
1.58E-11 |
| defense response |
2.05E-02 |
5.27E-02 |
1 |
| response to chemical stimulus |
2.22E-02 |
1.72E-13 |
1.23E-01 |
| response to stress |
2.32E-02 |
1.40E-07 |
1 |
| |
EGF 24&48 h UP |
SP 1&4 h DN |
EFNAs DN |
| biological process |
1.32E-02 |
9.37E-02 |
6.92E-03 |
| metabolic process |
3.16E-02 |
1.00E + 00 |
3.29E-02 |
| anatomical structure development |
4.50E-02 |
2.20E-01 |
1 |
| blood coagulation |
6.08E-02 |
3.59E-01 |
1 |
| |
EGF 24&48 h DN |
SP 1&4 h UP |
EFNAs UP |
| response to stress |
1.95E-06 |
5.34E-03 |
1 |
| response to external stimulus |
5.54E-04 |
1.08E-02 |
1 |
| regulation of cell proliferati |
2.87E-03 |
4.68E-06 |
1 |
| epidermis development |
5.18E-03 |
1 |
9.39E-09 |
| response to wounding |
8.27E-03 |
2.60E-02 |
1 |
| biological process |
1.45E-02 |
1.72E-03 |
5.83E-04 |
| negative regulation of proliferation |
1.56E-02 |
4.83E-02 |
1 |
| tissue development |
7.13E-02 |
1 |
1.52E-05 |
| regulation of apoptosis | 8.77E-02 | 9.18E-01 | 1 |
UP denotes induced, DN suppressed genes. Note that the genes induced by EGF are suppressed by EphrinAs and SP600125, and vice versa.