Table 5.
Kinases with common targets encoded by the EGF-, EphrinAs- and SP600125-regulated genes
| Kinase | EGF 1&4 h UP | SP 1&4 h DN | EFNAs DN |
|---|---|---|---|
| MAPK1 |
2.51E-07 |
1 |
1.22E-02 |
| SRC |
5.21E-06 |
1 |
1 |
| MAPK14 |
1.36E-05 |
1 |
1.88E-04 |
| EGFR |
1.39E-05 |
1 |
1 |
| INSR |
1.02E-04 |
1 |
1 |
| MAPK3 |
1.70E-04 |
1 |
5.05E-02 |
| JAK2 |
3.57E-04 |
1 |
1 |
| ROCK1 |
2.62E-03 |
1 |
1 |
| JAK1 |
3.30E-03 |
1 |
1 |
| PTK2 |
3.62E-03 |
1 |
1 |
| MAPK8 |
2.92E-02 |
1 |
1 |
| PRKCQ |
4.00E-02 |
1 |
1 |
| ERBB2 |
5.35E-02 |
1 |
1 |
| FYN |
5.36E-02 |
1 |
1 |
| JAK3 |
5.45E-02 |
1 |
1 |
| IGF1R |
7.63E-02 |
1 |
1 |
| PRKCD |
9.07E-02 |
1 |
1 |
| |
EGF 24&48 h DN |
SP 24&48 h UP |
EFNAs UP |
| CDK2 |
5.84E-03 |
1.43E-04 |
1 |
| CDC2 | 1.21E-02 | 2.45E-06 | 1 |
UP denotes induced, DN suppressed genes. All kinases with p-values better than 0.1 for the EGF-regulated targets are listed. No kinases common to all three agents were identified.