Table 2.
Descriptive statistics of diagnostic performance for severe malaria
| Parameter | Cut-off value | Sensitivity | Specificity | PPV | NPV | Youden’s | AUROC |
|---|---|---|---|---|---|---|---|
|
Total leukocyte count |
≥ 6.5 × 109/L |
0.59 (0.46-0.71) |
0.75 (0.71-0.80) |
0.28 (0.21-0.37) |
0.92 (0.88-0.95) |
0.34 |
0.70 (0.63-0.78) |
|
Neutrophil count |
≥ 3.4 × 109/L |
0.64 (0.51-0.76) |
0.56 (0.51-0.61) |
0.19 (0.14-0.25) |
0.91 (0.86-0.94) |
0.2 |
0.61 (0.53-0.69) |
|
Lymphocyte count |
< 0.7 × 109/L |
0.33 (0.22-0.46) |
0.72 (0.67-0.76) |
0.16 (0.10-0.24) |
0.87 (0.83-0.90) |
0.05 |
0.51 (0.43-0.59) |
|
NLCR |
≥ 2.8 |
0.77 (0.64-0.86) |
0.44 (0.39-0.49) |
0.18 (0.14-0.24) |
0.92 (0.87-0.96) |
0.21 |
0.57 (0.50-0.64) |
| CRP | >141 mg/L | 0.80 (0.67-0.89) | 0.76 (0.71-0.80) | 0.33 (0.25-0.42) | 0.96 (0.93-0.98) | 0.56 | 0.84 (0.79-0.89) |