Table 2.
Cases of post infantile Giant hepatitis with their prognostic outcome.
| Etiology | Number of cases | Prognostic outcome |
References |
|---|---|---|---|
| Drugs | |||
| Methotrexate | 2 | Good (mild hepatitis) | [1, 5] |
| Chlorpromazine | 1 | Good (mild hepatitis) | [1] |
| ISABGOL | 1 | Good (mild hepatitis) | [6] |
| Clometacine | 1 | Poor (acute liver failure) | [7] |
| Amoxicillin and Clavulanate |
1 | Poor (chronic hepatitis with acute decompensation) | [8] |
| Doxycycline | 1 | Poor (acute liver failure) Treated for a week for bacterial bronchitis |
[9] |
|
| |||
| Autoimmune | |||
| AIH | 5 | 1 (died) 4 Good (clinically improved) |
[1] |
| 2 | 1 Moderate (rapid onset of cirrhosis died) 1 Moderate (rapid onset of cirrhosis) |
[5] | |
| 10 | Moderate 25% (acute hepatitis), 42% moderate (chronic active hepatitis), 33% moderate to poor cirrhosis, >1-month duration | [2] |
|
| AIH | 13 | 4 Poor (liver failure) | [7] |
| 5 Moderate (rapid cirrhosis) | |||
| 4 Good (responded to immunosuppressants) | |||
| 1 | Moderate (rapid onset of cirrhosis) | [10] | |
| 1 | Good (responded to immunossuppresion) | [11] | |
| SLE | 2 | Moderate | [2, 12] |
| Autoimmune hemolytic anemia |
3 | Poor | [13–15] |
| PSC + AIH | 2 | Moderate (rapid onset of cirrhosis) Good (mild hepatitis) |
[16, 17] |
| AIH + polyarthritis | 1 | Moderate (early cirrhosis) | [18] |
| AIH + polyarteritis | 1 | Moderate (early cirrhosis) | [19] |
| AIH + UC | 1 | Moderate (early cirrhosis) | [20] |
| PBC | 2 | 1 Poor, (liver failure) 1 moderate (early cirrhosis) | [21, 22] |
| AIH II | 1 | Poor (died) | [23] |
|
| |||
| Viral | |||
| HAV | 4 | Poor (fatal liver failure) | [1, 24–26] |
| HEV | 1 | Good (mild hepatitis) | [27] |
| HBV | 3 | Good (1 acute hepatitis, 2 chronic hepatitis) | [2, 7] |
| HCV | 22 | Good (chronic hepatitis) | [5, 28–30] |
| EBV | 3 | Poor (fatal liver failure) | [31–33] |
| Paramyxoviruses | 13 | Poor (7 fatal liver failure, 6 died) | [3, 26, 34, 35] |
| HIV + HCV | 2 | Good (chronic hepatitis) | [30] |
| HIV | 2 | Good (chronic hepatitis) | [36] |
| HHV-6A | 1 | Good (chronic hepatitis) | [27] |
| CMV | 1 | Poor (acute liver failure with underlying Wilson's diseases) | [37] |
|
| |||
| Hypereosinophilia | 3 | 2 Poor (liver failure) 1 Good |
[24, 32, 38] |
| CLL | 3 | 2 Poor (liver failure) 1 Good (responded to immunosuppression) |
[39] |
| Posttransplant | 10 | Poor (recurrent disease, mostly required retransplant) | [40–43] |