Table 4.
Clinical chemistry of plasma from B6C3F1 mice administered aloe juice by gavage.
| Parameters—3 days post exposure | Control male | Aloe male | Control female | Aloe female |
|---|---|---|---|---|
| ALT (U/L) | 26.0 ± 3.5 | 23.0 ± 5.4 | 18.4 ± 2.0 | 19.7 ± 2.2 |
| ALP (U/L) | 64.2 ± 4.4 | 60.56 ± 7.3 | 87.8 ± 9.4 | 88.8 ± 16.4 |
| CK (U/L) | 287.6 ± 264.8 | 146.0 ± 114.7 | 85.4 ± 29.2 | 120.2 ± 68.3 |
| TBIL (mg/dL) | ≤0.1# | ≤0.1 | ≤0.1 | ≤0.1 |
| Total protein | 4.5 ± 0.23 | 4.3 ± 0.1* | 4.1 ± 0.13 | 4.0 ± 0.42 |
| BUN (mg/dL) | 18.0 ± 1.2 | 18.0 ± 1.4 | 22.8 ± 1.9 | 22.5 ± 1.1 |
| Creatinine (mg/dL) | ≤0.2# | ≤0.2 | ≤0.2 | ≤0.2 |
|
| ||||
| Parameters—14 days post exposure | ||||
|
| ||||
| ALT (U/L) | 25.2 ± 7.4 | 21.8 ± 6.5 | 23.2 ± 11.9 | 18.7 ± 2.4 |
| ALP (U/L) | 71.2 ± 18.0 | 67.4 ± 5.0 | 101.3 ± 3.9 | 86.2 ± 16.6 |
| CK (U/L) | 117.0 ± 14.3 | 169.2 ± 86.9 | 157.2 ± 105.5 | 196.0 ± 144.6 |
| TBIL (mg/dL) | ≤0.1# | ≤0.1 | ≤0.1 | ≤0.1 |
| Total protein | 3.8 ± 0.06 | 4.0 ± 0.3 | 3.8 ± 0.03 | 3.8 ± 0.2 |
| BUN (mg/dL) | 20.8 ± 4.0 | 21.8 ± 2.6 | 24.3 ± 2.3 | 22.2 ± 1.0 |
| Creatinine (mg/dL) | ≤0.2# | ≤0.2 | ≤0.2 | ≤0.2 |
Values expressed as mean ± s.d.
*P ≤ 0.05.
ALT: alanine aminotransferase activity; ALP: alkaline phosphatase Activity; CK: creatine kinase; TBIL: total bilirubin; BUN: blood urea nitrogen.
#Levels for TBIL and creatinine were at or below instrument quantitation threshold.