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. Author manuscript; available in PMC: 2013 Mar 26.
Published in final edited form as: Stat Med. 2010 Jul 30;29(17):1839–1856. doi: 10.1002/sim.3956

Table V.

The estimated population parameters and 95 per cent confidence intervals of them in the two component nonlinear mixed effects model.

Treatment Parameter 95 Per cent lower bound est. 95 Per cent upper bound
1 σ 0.076 0.085 0.094
t50 64.027 100.835 137.642
β 0.996 1.485 1.975
γ −2.105 −0.544 1.018
η 0.154 0.204 0.267
σt50 48.090 69.649 100.872
σβ 0.606 0.911 1.368
σγ 1.432 2.412 4.062
ση 0.058 0.102 0.152
cov(t50, β) 0.407 0.751 0.909
cov(t50, γ) −0.642 −0.146 0.435
cov(t50, η) 0.140 0.594 0.892
cov(β, γ) −0.688 −0.268 0.287
cov(β, η) −0.091 0.521 0.912
cov(γ, ρ) −0.668 −0.215 0.148
2 σ 0.054 0.061 0.068
t50 199.452 244.443 289.44
β 2.033 2.497 2.961
γ −1.722 0.775 3.272
η 0.141 0.198 0.272
σt50 35.519 60.099 101.690
σβ 0.322 0.585 1.062
σγ 1.836 3.269 5.823
ση 0.048 0.087 0.121
cov(t50, β) 0.012 0.687 0.932
cov(t50, γ) −0.014 0.643 0.912
cov(t50, η) −0.973 −0.028 0.614
cov(β, γ) −0.221 0.569 0.908
cov(β, η) −0.064 0.596 0.942
cov(γ, η) −0.910 0.041 0.838

The estimates were obtained by EMMCEM using the 14 horses which received the test meal without atropine (treatment = 1) and seven horses which received the test meal along with atropine (treatment = 2).