Table 1.
Region | Trait | Genes |
---|---|---|
1p32.3 |
LDL |
TMEM61, BSND, PCSK9, USP24 |
1p31.3 |
TG |
ANGPTL3*, DOCK7, ATG4C** |
1p13.3 |
LDL |
KIAA1324, SARS, CELSR2**, PSRC1, MYBPHL, SORT1 |
1p12 |
T2D |
ADAM30, NOTCH2 |
1q42.13 |
TG, HDL |
GALNT2 |
2p24.1 |
LDL |
APOB |
2p23.3 |
T2D |
NRBP1**, KRTCAP3, IFT172, FNDC4, GCKR, C2orf16, ZNF512 |
2p21 |
T2D |
THADA**, PLEKHH2 |
2q24.3 |
FG |
NOSTRIN*, SPC25, G6PC2, ABCB11** |
3p25.2 |
T2D |
PPARG** |
3p14.1 |
T2D |
ADAMTS9* |
3q27.3 |
T2D |
IGF2BP2*, C3orf65 |
5q13.3 |
LDL |
HMGCR, COL4A3BP |
6p22.3 |
T2D |
CDKAL1 |
6p21.32 |
LDL |
HLA-DPA1, COL11A2, RXRB**, SLC39A7, HSD17B8, MIR219-1, RING1**, VPS52, RPS18 |
7p15.2 |
T2D |
JAZF1 |
7p13 |
FG |
AEBP1, MIR4649, POLD2, MYL7, GCK**, YKT6, CAMK2B |
7q11.23 |
TG |
BAZ1B, BCL7B, TBL2, MLXIPL**, VPS37D, DNAJC30*, WBSCR22, STX1A |
8p21.3 |
TG, HDL |
LPL** |
8q24.11 |
T2D |
SLC30A8* |
8q24.13 |
TG |
TRIB1* |
9p21.3 |
T2D |
MTAP, CDKN2A, CDKN2B |
9q31.1 |
HDL |
ABCA1 |
10p13 |
T2D |
NUDT5, CDC123, CAMK1D |
10q23.33 |
T2D |
IDE*, KIF11*, HHEX** |
10q25.2 |
T2D |
TCF7L2** |
11p15.1 |
T2D |
NUCB2*, NCR3LG1, KCNJ11**, ABCC8* |
11p11.2 |
T2D |
EXT2, ALX4 |
11q23.3 |
TG |
BUD13, ZNF259, APOA5, APOA4, APOC3, APOA1, SIK3 |
12q15 |
T2D |
TSPAN8, LGR5 |
12q23.3 |
HDL |
MYO1H, KCTD10*, UBE3B, MMAB, MVK** |
15q21.3 |
HDL |
LIPC** |
16q12.1 |
T2D |
RPGRIP1L, FTO |
16q12.2 |
HDL |
CETP, NLRC5, SLC12A3**, HERPUD1, MIR138-2 |
18q21.1 |
HDL |
LIPG**, ACAA2 |
19p13.2 |
LDL |
SMARCA4, LDLR, SPC24, KANK2 |
19p13.11 |
TG, LDL |
GATAD2A, TSSK6, NDUFA13**, YJEFN3, CILP2, PBX4, LPAR2, GMIP, ATP13A1** |
19q13.33 | LDL | BCL3, CBC, BCAM, PVRL2, TOMM40**, APOE, APOC1, APOC4, APOC2, CLPTM1, RELB** |
List of all human genes located near the SNPs considered in the study. Asterisks indicate genes with Drosophila orthologs that function in sucrose tolerance in Drosophila; doubled asterisks indicate strong hits. Italicized genes were not evaluated in the Drosophila sucrose-intolerance screen, mostly because they lack Drosophila orthologs. References and more detailed experimental results are in Additional file 1: Table S1.