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Effect of inhibitors on SK1 or SK2 activity. SK1 activity was measured using 3 µM sphingosine and 250 µM ATP. SK2 activity was assayed using 10 µM sphingosine and 250 µM ATP (n = 3 for each compound, results expressed as mean inhibition +/− S.D). RB series compounds were used at 50 µM. BML-258 (50 µM) inhibited SK1 activity by 74.5 +/− 3.3 % (n = 3). The control is 100% and equals activity against Sph alone.
