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RB-020 (50 µM) is a substrate of SK1 and SK2 and an inhibitor of SK1 activity against sphingosine (Sph).
| SK1 activity (% control) |
SK2 activity (% control) |
|
|---|---|---|
| Sph | 100 ± 4.4 | 100 ± 12.8 |
| Sph + RB-020 | 34.4 ± 4.1 | 315 ± 5.1 |
| RB-020 | 27.5 ± 3.0 | 228 ± 17.9 |
Sph was used at 3 and 10 µM for SK1 and SK2, respectively. Results are represented as % activities +/− SD (n = 3 assays) of control (where 100% equals activity against Sph alone).a
