Table 3.

Sitting and orthostatic changes in blood pressure and heart rate in the three groups during the study period.

		Lisinopril	Candesartan	HCTZ	Between group P-value
	N	17	17	13
Sitting
Systolic Blood Pressure, mm Hg	Baseline	153±3	150±3	156±3	0.93
	6 months	129±4	130±4	132±4
	12 month	126±4	124±5	131±5
	Within-group p-value	<0.0001	0.0001	<0.0001
Diastolic Blood Pressure, mm Hg	Baseline	85±2	81±2	83±2	0.63
	6 months	72±2	71±2	76±2
	12 month	70±3	69±3	74±3
	Within-group p-value	<0.0001	0.001	0.03
Heart Rate, BPM	Baseline	64±2	65±2	66±3	0.28
	6 months	63±3	67±3	64±3
	12 month	65±3	63±4	73±4
	Within-group p-value	0.74	0.58	0.09
1-minute orthostatic change*
Systolic Blood Pressure, mm Hg	Baseline	−5±2	−10±2	−10±2	0.77
	6 months	−3±2	−7±3	−4±3
	12 month	−3±3	−9±3	−4±3
	Within-group p-value	0.71	0.59	0.08
Diastolic Blood Pressure, mm Hg	Baseline	1±2	−2±2	−3±2	0.24
	6 months	−2±2	−2±2	−1±2
	12 month	−1±2	−5±3	3±3
	Within-group p-value	0.36	0.73	0.20
Heart Rate, BPM	Baseline	2±1	2±1	1±1	0.66
	6 months	5±1	3±1	5±1
	12 month	5±2	4±2	6±2
	Within-group p-value	0.06	0.67	0.04
3-minutes orthostatic change
Systolic Blood Pressure, mm Hg	Baseline	1±2	−1±2	−1±2	0.78
	6 months	4±2	−2±3	1±2
	12 month	2±2	−2±4	−2±3
	Within-group p-value	0.43	0.84	0.65
Diastolic Blood Pressure, mm Hg	Baseline	3±1	−2±1	0±1	0.16
	6 months	1±1	1±2	2±2
	12 month	2±2	3±2	4±2
	Within-group p-value	0.65	0.04	0.17
Heart Rate, BPM	Baseline	2±1	2±1	2±1	0.27
	6 months	3±1	3±1	3±1
	12 month	3±1	2±2	8±2
	Within-group p-value	0.48	0.89	0.03

Numbers are age-adjusted least square means± standard error.

^*Orthostatic =Standing measure-sitting measure