Table 2.

Glucose tolerance tests of pre- and post-surgical male or female Lepr^flox/flox and Pomc-Cre, Lepr^flox/flox mice.

	Baseline glucose (mg/dL)	Area under the glucose curve	15 min Insulin (ng/ml)	Baseline glucose (mg/dL)	Area under the glucose curve	15 min Insulin (ng/ml)
Pre-surgical	Leprflox/flox mice			Pomc-Cre, Leprflox/flox mice
Sham Male	116.29 ± 4.54	2021.79 ± 460.76	8.29 ± 2.02	122.78 ± 6.71	4348.33 ± 495.47 *†	19.88 ± 5.19 *
Sham Female	96.34 ± 3.58	2638.59 ± 298.69	11.03 ± 1.97	96.15 ± 7.29	2817.75 ± 292.78	10.98 ± 2.84
OVX Female	92.50 ± 2.62	2485.96 ± 349.89	12.89 ± 2.51	101.50 ± 9.04	2913.75 ± 408.34	15.67 ± 4.48
Post-surgical	Leprflox/flox mice			Pomc-Cre, Leprflox/flox mice
Sham Male	101.00 ± 6.63	3949.82 ± 900.16	8.13 ± 1.96	125.61 ± 8.93 *	5622.92 ± 516.03 †	14.74 ± 3.76 *
Sham Female	102.25 ± 9.39	2611.88 ± 363.76	10.86 ± 2.13	101.75 ± 7.83	2944.69 ± 354.99	12.36 ± 3.04
OVX Female	101.12 ± 4.44	3521.83 ± 229.52 #	9.57 ± 1.67	104.86 ± 7.28	3343.39± 390.67	19.97 ± 3.15 *

^*denotes significant difference between genotypes within sex-procedure (e.g., Lepr^flox/flox vs. Pomc-Cre, Lepr^flox/flox within Sham Male).

^†denotes significant difference between sex-procedures within genotype (e.g., Male Sham vs. Female Sham vs. Female OVX within Pomc-Cre, Lepr^flox/flox).

^#denotes significant difference before and after surgeries within same sex-procedure and genotype (e.g., before vs. after for OVX Female Lepr^flox/flox).

P < 0.05