Table 1.

Concentrations of progesterone and 3α,5α-THP in diencephalon, cortex, hippocampus, and midbrain of diestrous female, proestrous female, and male rats administered 0, 5, 10, or 20 mg/kg intraperitoneal cocaine (n = 9–12/group).

	Diestrous				Proestrous				Male
Cocaine dose (mg/kg)	0	5	10	20	0	5	10	20	0	5	10	20
Progesterone concentration (ng/g±SEM)
Diencephalon	6.8±1.7	5.6±1.8	7.8±1.8	16.8±1.9*	12.3±2.8	8.9±2.5	7.8±1.9*	18.3±2.3*	7.8±1.4	3.9±1.7*	4.7±0.6*	9.3±1.1
Cortex	3.5±0.9	3.7±1.1	3.9±1.0	8.3±1.1	5.9±1.3	3.2±0.6*	2.9±0.4*	8.1±0.8*	3.1±0.6	1.3±0.2	1.9±0.2	5.0±0.7*
Hippocampus	4.1±1.0	3.8±1.1	3.7±0.7	9.5±0.9*	6.9±1.5	3.4±0.5*	3.0±0.4*	9.1±1.0*	3.1±0.6	1.3±0.2*	2.3±0.3	4.8±0.5*
Midbrain	8.7±2.4	10.5±3.4	13.5±4.1	23.0±3.2*	14.9±3.4	8.0±1.3*	8.5±1.9*	22.6±2.8*	9.6±1.8	3.3±0.5*	7.8±0.9	17.0±2.7*
Serum	5.1±0.4	4.5±0.9	6.1±0.2*	2.5±0.7*	6.2±0.6	4.1±1.1*	6.2±0.2	4.7±1.0*	4.9±0.6	6.0±0.2*	6.4±0.3*	3.0±0.8*
3α,5α-THP (ng/g ± SEM)
Diencephalon	21.9±3.7	13.5±2.7*	6.5±1.9*	27.2±6.2	40.6±13.9	9.7±4.5*	10.5±2.4*	33.0±5.3	7.5±2.7	4.4±0.5*	10.5±2.4	33.0±5.3*
Cortex	22.1±6.3	14.7±3.0	9.0±2.8*	29.4±5.9	32.6±7.5	22.8±9.1	14.0±3.4*	38.3±8.4	7.4±2.2	5.0±1.0	2.9±0.4*	17.3±2.6*
Hippocampus	16.0±3.0	16.8±3.0	6.6±1.7*	22.3±4.0	43.3±10	17.3±4.5*	16.0±6.4*	43.8±10.3	10.7±4.6	8.6±1.6	5.7±0.8	38.9±8.1*
Midbrain	32.3±6.0	46.5±12.8	19.6±6.6*	43.3±7.2	57.1±15.3	35.1±13.9	24.1±7.8*	89.0±23.0	28.2±15.2	12.7±2.3	13.1±2.8	43.7±7.6
Serum	1.6+0.2	2.6+0.5*	1.6+0.5	1.8+0.5	2.6+0.4	4.5+0.1*	0.5+0.1*	0.8+0.3*	1.9+0.3	3.2+0.4*	0.8+0.3*	2.8+0.3*

^*indicates significant difference compared to vehicle, p<0.05.