Table 1. List of Simulated PfSUB1-Peptide Complex Structuresa.
| native sequences | processing site identity | notes |
|---|---|---|
| LVSAD↓NIDIS | PfSUB1 | internal cleavage site |
| KITAQ↓DDEES | SERA4 site 1 | most efficiently cleaved peptide |
| EIKAE↓TEDDD | SERA5 site 1 | variation at P1 and P1′-P5′ |
| KVKAQ↓DDFNP | SERA6 site 1 | P1′ = D; P3′ not polar |
| VVTGE↓AISVT | MSP1-42 | P1′ not polar |
| prime side variations | notes |
|---|---|
| KITAQ↓ADEES | single Ala mutation |
| KITAQ↓ADAES | double Ala mutation |
| KITAQ↓ADDES | double mutation |
| KITAQ↓AAAAA | quintuple Ala mutation |
| KITAQ↓D |
a
Downward-pointing arrow denotes the scissile bond.