Table 2.
Outcome Ascertainment for INSIGHT
|
Follow up time since initial onset (months) |
|||||||
|---|---|---|---|---|---|---|---|
| 4 | 8 | 12 | 24 | 36 | 48 | 60 | |
|
Clinical |
|
|
|
|
|
|
|
|
Remission: Urine protein/creatinine < 0.2 or Albustik negative or trace for 3 consecutive days |
x |
x |
x |
x |
x |
x |
x |
|
Relapse: After remission, an increase in the first morning urine protein/creatinine ≥2 for 3 of 5 consecutive days |
x |
x |
x |
x |
x |
x |
x |
|
Frequently relapsing NS: 4 or more relapses within 1 year OR 2 or more relapses within 6 months |
|
|
x |
x |
x |
x |
x |
|
Steroid dependant NS: Relapse during steroid taper or within 14 days of steroid discontinuation |
x |
x |
x |
x |
x |
x |
x |
|
Steroid resistant: Inability to induce remission within 28 days of steroid therapy |
x |
x |
x |
x |
x |
|
|
|
Laboratory |
|||||||
|
Urine protein/creatinine: Abnormal if > 250 mg/mmol |
x |
x |
x |
x |
x |
x |
x |
|
Urine albumin/creatinine: Abnormal if > 30 mg/mol |
x |
x |
x |
x |
x |
x |
x |
|
Creatinine based eGFR: eGFR by modified Schwartz (ml/min/1.73 m2) = k x height/serum creatinine |
x |
x |
x |
x |
x |
x |
x |
| CKD/ESRD: eGFR < 60 ml/min/1.73 m2 (or dialysis) | Anytime | ||||||