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. Author manuscript; available in PMC: 2013 Mar 26.
Published in final edited form as: Phys Rev Lett. 2013 Mar 5;110(10):108102. doi: 10.1103/PhysRevLett.110.108102

FIG. 3.

FIG. 3

Dynamics of VWF multimers. The data were taken at 1000 nm/s pulling velocity. (a) Peak force distributions of spVWF as a function of time since exposure to a pathological level of 100 dyn/cm2 fluid shear. (b) spVWF peak force decreases with time since shear exposure. The solid line is a fit to an exponential curve, F (t) = Fp + (Fs − Fp) exp(−t/τ) (see text). The error bars are half of the bin width in the histogram. (c) Number of unfolding peaks in a given force curve from different forms of VWF multimers. pVWF dimer has up to four force peaks, indicating that there are two unfolding events per monomer.