Table 2.

Patients who met each definition of sustained progression during followup.

	Patients with sustained progression		Patient with sustained progression and subsequent visits		Patients who always progressed among those with subsequent visits
	Number	Percent of all patients	Number	Percent of those with sustained progression	Number	Percent of those with subsequent visits
EDSS
(D1) Increase of 0.5	392	42.2	315	80.4	137	43.5
(D2) Increase of 1	278	29.9	225	80.9	98	43.6
(D3) Increase of 1.5	147	15.8	120	81.6	61	50.8
(D4) Increase of 1/increase 1.5 for baseline EDSS = 0	212	22.8	169	79.7	73	43.2
Functional system
(D5) Pyramidal function	217	23.4	179	82.5	53	29.6
(D6) Cerebellar function	120	12.9	94	78.3	29	30.9
(D7) Brainstem function	89	9.6	62	69.7	13	21
(D8) Sensory function	271	29.2	226	83.4	75	33.2
(D9) Bowel bladder function	179	19.3	135	75.4	38	28.1
(D10) Mental function	161	17.3	112	69.6	40	35.7
(D11) Visual function	91	9.8	73	80.2	16	21.9
Combination of functional system
(D12) Any FS	536	57.7	433	80.8	228	52.7
(D13) First FS	536	57.7	433	80.8	122	28.2
(D14) Sum of subscales increase of 2	243	26.2	187	77	85	45.5
(D15) Sum of subscales increase of 3	148	15.9	111	75	49	44.1

A total of 929 patients contributed to the analysis. EDSS: expanded disability status scale.