Table 3.
Proportion of patients who experienced sustained increases in functional systems associated with sustained progression on the EDSS.
| (D1) Increase of 0.5 on the EDSS | (D2) Increase of 1 on the EDSS | (D3) Increase of 1.5 on the EDSS | (D4) Increase of 1/1.5 on the EDSS based on baseline EDSS | |
|---|---|---|---|---|
| Total progressed | 392 | 278 | 147 | 212 |
| Number (%) progressed on pyramidal scale | 119 (30.4) | 96 (34.5) | 65 (44.2) | 88 (41.5) |
| Number (%) progressed on cerebellar scale | 40 (10.2) | 27 (9.7) | 25 (17.0) | 27 (12.7) |
| Number (%) progressed on brainstem scale | 26 (6.6) | 21 (7.6) | 19 (12.9) | 21 (9.9) |
| Number (%) progressed on sensory scale | 140 (35.7) | 113 (40.6) | 83 (56.5) | 104 (49.1) |
| Number (%) progressed on bowel bladder scale | 66 (16.8) | 55 (19.8) | 39 (26.5) | 55 (25.9) |
| Number (%) progressed on mental scale | 59 (15.1) | 46 (16.5) | 31 (21.1) | 44 (20.8) |
| Number (%) progressed on visual scale | 32 (8.2) | 26 (9.4) | 20 (13.6) | 27 (12.7) |
| Number (%) progressed on multiple scales | 124 (31.6) | 105 (37.8) | 92 (62.6) | 118 (55.7) |
| Number (%) progressed on no scale | 81 (20.7) | 47 (16.9) | 5 (3.4) | 15 (7.1) |
EDSS: expanded disability status scale.