Table 1.
Clinical characteristics at time of initial brain metastases
| Characteristics | N | Range |
|---|---|---|
| Median age at BM Dx |
56.1 years |
31.2-79.0 |
| Median interval from EOC Dx to BM |
3.4 years |
0.08-26.8 |
| Median interval from EOC Dx to BM in stage I-II EOC |
5.9 years |
3.7-10.8 |
| Median interval from EOC Dx to BM in stage III-IV EOC |
3.1 years |
0.08-26.8 |
| |
Number |
Percent |
| Age <65 |
52 |
87% |
| Age ≥65 |
8 |
13% |
| KPS <70 |
9 |
15% |
| KPS ≥70 |
42 |
70% |
| KPS unknown |
9 |
15% |
| Number of BM at initial BM Dx: |
|
|
| 1 |
28 |
46.7% |
| 2-3 |
10 |
16.7% |
| ≥4 |
16 |
26.7% |
| LMD |
6 |
10% |
| Location of initial BM: |
|
|
| Cerebral hemispheres |
29 |
48% |
| Cerebellum |
10 |
17% |
| Both |
21 |
35% |
| Extracranial metastases at time of BM Dx: |
|
|
| None |
10 |
17% |
| Limited and stable |
11 |
18% |
| Limited and progressive |
11 |
18% |
| Extensive and stable |
11 |
18% |
| Extensive and progressive |
16 |
27% |
| Unknown |
1 |
2% |
| Primary tumor status (abdomen): |
|
|
| Controlled |
36 |
60% |
| Uncontrolled |
23 |
38% |
| Unknown |
1 |
2% |
| Chemotherapy in 3 months preceding BM Dx: |
|
|
| Yes |
37 |
62% |
| No | 23 | 38% |
BM = brain metastasis; Dx = diagnosis; EOC = epithelial ovarian cancer; KPS = Karnofsky Performance Score; LMD = leptomeningeal disease.