Table 2.
Multivariate analysis of overall survival using Cox proportional hazard model
|
Variable |
Event(n)/ |
Hazard ratio |
p Value |
|---|---|---|---|
| Total (n) | |||
| KPS at BM diagnosis |
|
|
|
| ≥70 (reference) |
37/42 |
1.00 |
|
| <70 |
9/9 |
2.86 |
0.018 |
| Primary tumor controlled in abdomen |
|
|
|
| Yes (reference) |
31/36 |
1.00 |
|
| No |
23/23 |
2.84 |
0.008 |
| Number of BM or LMD |
|
|
|
| 1 (reference) |
24/28 |
1.00 |
|
| 2-3 |
8/10 |
1.51 |
0.490 |
| 4+ |
16/16 |
3.18 |
0.053 |
| LMD | 6/6 | 8.22 | 0.013 |
Event = death. BM = brain metastasis; KPS = Karnofsky Performance Score; LMD = leptomeningeal disease.