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Optimization of Conditions
| entry | RX | n | type of zinca | TMEDA (equiv) | product | yield (%)b | ArBr recovered (%) |
|---|---|---|---|---|---|---|---|
| 1 |
|
2.5 | powder | 0.5 | 2 | 86 (45c) | 10 |
| 2 | 0 | 36 | 65 | ||||
| 3 | EtO2C–(CH2)5–Br | 2 | dust | 1 | 3 | 72 (32c) | 18 |
| 4 | 0 | 15 | 79 | ||||
| 5 | EtO2C–(CH2)5–Br | 1.5 | dust | 1 | 4 | 65 | 22 |
| 6 | n-C10H21–Br | 1.5 | dust | 3d | 1 | 56 (18c) | 35 |
| 7 | 0d | traces | 78 |
6 mmol of zinc was used in all cases.
Isolated yield.
In the absence of Brij 30.
Run over 72 h.
