Table 3.

Summary of metabolite profiles (up to 96 h) in selected female mouse tissues and excreta after receiving 3 mg/kg of a single oral dose of either α- or γ-[¹⁴C]HBCD in corn oil.

Matrix	Time (h)	%Dose	%Dose as Free Metabolites	%Dose as Non-extractables	Total Metabolites (%Dose)
α-HBCD
Urine	0-24	15	15	---	15
	24-48	2	2	---	2
	48-72	1	1	---	1
	72-96	0.5	0.5	---	0.5
Feces	0-24	42	14.3	12.2	26.5
	24-48	3	0.9	1.7	2.2
	48-72	2	1.0	0.9	1.9
	72-96	1	0.6	0.3	0.9
Adipose	3	0.006	0.0007	0	0.0007
Brain	3	1.2	0.68	0	0.68
Liver	3	2.7	0.5	0.6	1.1
Serum	3	1.3	1.3	---	1.3
γ-HBCD
Urine	0-24	25	25	---	25
	24-48	2	2	---	2
	48-72	1	1	---	1
	72-96	0.5	0.5	---	0.5
Feces	0-24	52	16.4	27.6	44.0
	24-48	6	2.0	2.7	4.7
	48-72	1	0.01	0.03	0.04
	72-96	0.5	0.3	0.02	0.3
Adipose	3	0.008	0.008	0	0.002
Brain	3	0.035	0.035	0	0.035
Liver	3	0.24	0.18	0.04	0.22
Serum	3	0.08	0.08	---	0.08